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CCL25

GENERAL INFORMATION

Gene name

 CCL25

Gene description

 Chemokine (C-C motif) ligand 25

Protein class

 Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (small intestine, duodenum)
GTEx:Tissue enriched (small intestine)
FANTOM5:Group enriched (small intestine, colon)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in a few tissues.

DATA RELIABILITY

Data reliability
description

 Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Presumed off target binding observed and disregarded.

Reliability score

 Uncertain based on 1 antibody.
HPA055883
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Small intestine

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (small intestine, duodenum)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (small intestine)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (small intestine, colon)

GENE INFORMATION

Gene name

 CCL25 (HGNC Symbol)

Synonyms

 Ckb15, SCYA25, TECK

Description

 Chemokine (C-C motif) ligand 25 (HGNC Symbol)

Entrez gene summary

 This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for dendritic cells, thymocytes, and activated macrophages but is inactive on peripheral blood lymphocytes and neutrophils. The product of this gene binds to chemokine receptor CCR9. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]

Chromosome

 19

Cytoband

 p13.2

Chromosome location (bp)

 8052767 - 8062650

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000131142 (version 83.38)

Entrez gene

 6370

UniProt

 O15444 (UniProt - Evidence at protein level)

neXtProt

 NX_O15444

Antibodypedia

 CCL25 antibodies

PROTEIN BROWSER
CCL25-001
CCL25-003
CCL25-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CCL25-001
ENSP00000253451
ENST00000253451
O15444 [Direct mapping]
C-C motif chemokine 25
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   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0001954 [positive regulation of cell-matrix adhesion]
GO:0002548 [monocyte chemotaxis]
GO:0005179 [hormone activity]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0006935 [chemotaxis]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0008009 [chemokine activity]
GO:0030593 [neutrophil chemotaxis]
GO:0031735 [CCR10 chemokine receptor binding]
GO:0042379 [chemokine receptor binding]
GO:0043547 [positive regulation of GTPase activity]
GO:0048247 [lymphocyte chemotaxis]
GO:0060326 [cell chemotaxis]
GO:0070098 [chemokine-mediated signaling pathway]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071346 [cellular response to interferon-gamma]
GO:0071347 [cellular response to interleukin-1]
GO:0071356 [cellular response to tumor necrosis factor]
GO:1903237 [negative regulation of leukocyte tethering or rolling]
Show all
 149 aa
16.5 kDa 		Yes 0
CCL25-003
ENSP00000375086
ENST00000390669
O15444 [Direct mapping]
C-C motif chemokine 25
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0001954 [positive regulation of cell-matrix adhesion]
GO:0002548 [monocyte chemotaxis]
GO:0005179 [hormone activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0006935 [chemotaxis]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0008009 [chemokine activity]
GO:0030593 [neutrophil chemotaxis]
GO:0031735 [CCR10 chemokine receptor binding]
GO:0042379 [chemokine receptor binding]
GO:0043547 [positive regulation of GTPase activity]
GO:0048247 [lymphocyte chemotaxis]
GO:0050900 [leukocyte migration]
GO:0060326 [cell chemotaxis]
GO:0070098 [chemokine-mediated signaling pathway]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071346 [cellular response to interferon-gamma]
GO:0071347 [cellular response to interleukin-1]
GO:0071356 [cellular response to tumor necrosis factor]
GO:1903237 [negative regulation of leukocyte tethering or rolling]
Show all
 150 aa
16.6 kDa 		Yes 0
CCL25-201
ENSP00000324756
ENST00000315626
C9JDZ7 [Direct mapping]
C-C motif chemokine 25
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0005576 [extracellular region]
GO:0006955 [immune response]
GO:0008009 [chemokine activity]
GO:0060326 [cell chemotaxis]
Show all
 150 aa
16.6 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.