Cell atlas - COX4I1 - The Human Protein Atlas

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COX4I1

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TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Mitochondria

Human cell
	Mitochondria

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GENERAL INFORMATION
Gene name	COX4I1
Gene description	Cytochrome c oxidase subunit IV isoform 1
Protein class	Predicted intracellular proteins Predicted membrane proteins Transporters
Predicted localization	Intracellular,Membrane
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the mitochondria.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Mitochondria (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA002485
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the mitochondria.

Main location

Mitochondria (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA002485	A-431	Mitochondria
	HPA002485	U-2 OS	Nucleus
	HPA002485	U-2 OS	Mitochondria
	HPA002485	U-251 MG	Nucleus
	HPA002485	U-251 MG	Mitochondria

GENE INFORMATION
Gene name	COX4I1 (HGNC Symbol)
Synonyms	COX4, COX4-1
Description	Cytochrome c oxidase subunit IV isoform 1 (HGNC Symbol)
Entrez gene summary	Cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer and proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit IV isoform 1 of the human mitochondrial respiratory chain enzyme. It is located at the 3' of the NOC4 (neighbor of COX4) gene in a head-to-head orientation, and shares a promoter with it. [provided by RefSeq, Jul 2008]
Chromosome	16
Cytoband	q24.1
Chromosome location (bp)	85798633 - 85807044
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000131143 (version 83.38)
Entrez gene	1327
UniProt	P13073 (UniProt - Evidence at protein level)
neXtProt	NX_P13073
Antibodypedia	COX4I1 antibodies

PROTEIN BROWSER

COX4I1-001	COX4I1-004	COX4I1-006	COX4I1-009	COX4I1-011	COX4I1-013	COX4I1-016

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
COX4I1-001 ENSP00000253452 ENST00000253452	P13073 [Direct mapping] Cytochrome c oxidase subunit 4 isoform 1, mitochondrial Show all	Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004129 [cytochrome-c oxidase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005751 [mitochondrial respiratory chain complex IV] GO:0006091 [generation of precursor metabolites and energy] GO:0006123 [mitochondrial electron transport, cytochrome c to oxygen] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0009060 [aerobic respiration] GO:0010467 [gene expression] GO:0016020 [membrane] GO:0022904 [respiratory electron transport chain] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:0070062 [extracellular exosome] GO:1902600 [hydrogen ion transmembrane transport] Show all	169 aa 19.6 kDa	No	1
COX4I1-004 ENSP00000454714 ENST00000564903	H3BN72 [Direct mapping] Cytochrome c oxidase subunit 4 isoform 1, mitochondrial Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004129 [cytochrome-c oxidase activity] GO:0005634 [nucleus] GO:0005739 [mitochondrion] GO:0016021 [integral component of membrane] GO:1902600 [hydrogen ion transmembrane transport] Show all	126 aa 14.4 kDa	No	1
COX4I1-006 ENSP00000454869 ENST00000565078	H3BNI5 [Direct mapping] Cytochrome c oxidase subunit 4 isoform 1, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004129 [cytochrome-c oxidase activity] GO:1902600 [hydrogen ion transmembrane transport] Show all	43 aa 4.8 kDa	No	0
COX4I1-009 ENSP00000457015 ENST00000561569	P13073 [Direct mapping] Cytochrome c oxidase subunit 4 isoform 1, mitochondrial Show all	Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004129 [cytochrome-c oxidase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005751 [mitochondrial respiratory chain complex IV] GO:0006091 [generation of precursor metabolites and energy] GO:0006123 [mitochondrial electron transport, cytochrome c to oxygen] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0009060 [aerobic respiration] GO:0010467 [gene expression] GO:0016020 [membrane] GO:0022904 [respiratory electron transport chain] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:0070062 [extracellular exosome] GO:1902600 [hydrogen ion transmembrane transport] Show all	169 aa 19.6 kDa	No	1
COX4I1-011 ENSP00000455030 ENST00000568794	H3BNV9 [Direct mapping] Cytochrome c oxidase subunit 4 isoform 1, mitochondrial Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004129 [cytochrome-c oxidase activity] GO:0005634 [nucleus] GO:0005739 [mitochondrion] GO:0016021 [integral component of membrane] GO:1902600 [hydrogen ion transmembrane transport] Show all	139 aa 15.7 kDa	No	1
COX4I1-013 ENSP00000455301 ENST00000566405	H3BPG0 [Direct mapping] Cytochrome c oxidase subunit 4 isoform 1, mitochondrial Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004129 [cytochrome-c oxidase activity] GO:0016021 [integral component of membrane] GO:1902600 [hydrogen ion transmembrane transport] Show all	108 aa 12.6 kDa	No	1
COX4I1-016 ENSP00000457513 ENST00000562336	P13073 [Direct mapping] Cytochrome c oxidase subunit 4 isoform 1, mitochondrial Show all	Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004129 [cytochrome-c oxidase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005751 [mitochondrial respiratory chain complex IV] GO:0006091 [generation of precursor metabolites and energy] GO:0006123 [mitochondrial electron transport, cytochrome c to oxygen] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0007584 [response to nutrient] GO:0009060 [aerobic respiration] GO:0010467 [gene expression] GO:0016020 [membrane] GO:0022904 [respiratory electron transport chain] GO:0031966 [mitochondrial membrane] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:0070062 [extracellular exosome] GO:1902600 [hydrogen ion transmembrane transport] Show all	169 aa 19.6 kDa	No	1

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.