Expression of COX7B in cancer - Summary

CANCER ATLAS

Gene description

Cytochrome c oxidase subunit VIIb

Protein class

Disease related genes, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Endometrial cancer

STAINING SUMMARY

HPA058041

GENE INFORMATION
Gene name	COX7B
Synonyms
Description	Cytochrome c oxidase subunit VIIb (HGNC Symbol)
Entrez gene summary	Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes subunit VIIb, which is highly similar to bovine COX VIIb protein and is found in all tissues. This gene may have several pseudogenes on chromosomes 1, 2, 20 and 22. [provided by RefSeq, Jun 2011]
Chromosome	X
Cytoband	q21.1
Chromosome location (bp)	77899438 - 77907373
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000131174 (version 83.38)
Entrez gene	1349
UniProt	P24311 (UniProt - Evidence at protein level)
neXtProt	NX_P24311
Antibodypedia	COX7B antibodies

PROTEIN BROWSER

COX7B-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
COX7B-001 ENSP00000417656 ENST00000481445	P24311 [Direct mapping] Cytochrome c oxidase subunit 7B, mitochondrial Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0004129 [cytochrome-c oxidase activity] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005746 [mitochondrial respiratory chain] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0007417 [central nervous system development] GO:0010467 [gene expression] GO:0016021 [integral component of membrane] GO:0022904 [respiratory electron transport chain] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:0045277 [respiratory chain complex IV] GO:1902600 [hydrogen ion transmembrane transport] Show all	80 aa 9.2 kDa	No	1