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SLC34A1

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GENERAL INFORMATION

Gene name

 SLC34A1

Gene description

 Solute carrier family 34 (type II sodium/phosphate cotransporter), member 1

Protein class

 Disease related genes
Plasma proteins
Potential drug targets
Predicted intracellular proteins
Predicted membrane proteins
Transporters

Predicted localization

 Intracellular,Membrane

Number of transcripts

 3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Group enriched (HEL, U-937)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (HEL, U-937)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 SLC34A1 (HGNC Symbol)

Synonyms

 NAPI-3, NPT2, NPTIIa, SLC11, SLC17A2

Description

 Solute carrier family 34 (type II sodium/phosphate cotransporter), member 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the type II sodium-phosphate cotransporter family. Mutations in this gene are associated with hypophosphatemia nephrolithiasis/osteoporosis 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009]

Chromosome

 5

Cytoband

 q35.3

Chromosome location (bp)

 177379235 - 177398848

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000131183 (version 83.38)

Entrez gene

 6569

UniProt

 Q06495 (UniProt - Evidence at protein level)

neXtProt

 NX_Q06495

Antibodypedia

 SLC34A1 antibodies

PROTEIN BROWSER
SLC34A1-001
SLC34A1-002
SLC34A1-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SLC34A1-001
ENSP00000321424
ENST00000324417
Q06495 [Direct mapping]
Sodium-dependent phosphate transport protein 2A
A0A024R7R9 [Target identity:100%; Query identity:100%]
Solute carrier family 34 (Sodium phosphate), member 1, isoform CRA_b
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   9TM proteins predicted by MDM
Plasma proteins
Disease related genes
Potential drug targets
Show all
GO:0001503 [ossification]
GO:0001822 [kidney development]
GO:0005515 [protein binding]
GO:0005768 [endosome]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006811 [ion transport]
GO:0006814 [sodium ion transport]
GO:0006817 [phosphate ion transport]
GO:0007584 [response to nutrient]
GO:0009100 [glycoprotein metabolic process]
GO:0009986 [cell surface]
GO:0010288 [response to lead ion]
GO:0015293 [symporter activity]
GO:0015321 [sodium-dependent phosphate transmembrane transporter activity]
GO:0016020 [membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0030165 [PDZ domain binding]
GO:0031226 [intrinsic component of plasma membrane]
GO:0031526 [brush border membrane]
GO:0031988 [membrane-bounded vesicle]
GO:0032026 [response to magnesium ion]
GO:0032355 [response to estradiol]
GO:0032403 [protein complex binding]
GO:0033189 [response to vitamin A]
GO:0035864 [response to potassium ion]
GO:0042431 [indole metabolic process]
GO:0042493 [response to drug]
GO:0042803 [protein homodimerization activity]
GO:0043434 [response to peptide hormone]
GO:0044267 [cellular protein metabolic process]
GO:0044341 [sodium-dependent phosphate transport]
GO:0045121 [membrane raft]
GO:0045838 [positive regulation of membrane potential]
GO:0046686 [response to cadmium ion]
GO:0046689 [response to mercury ion]
GO:0046849 [bone remodeling]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051260 [protein homooligomerization]
GO:0055062 [phosphate ion homeostasis]
GO:0055085 [transmembrane transport]
GO:0060416 [response to growth hormone]
GO:0071107 [response to parathyroid hormone]
GO:0071248 [cellular response to metal ion]
GO:0071374 [cellular response to parathyroid hormone stimulus]
GO:0072350 [tricarboxylic acid metabolic process]
GO:0072734 [cellular response to staurosporine]
GO:0097066 [response to thyroid hormone]
GO:0097187 [dentinogenesis]
GO:1901128 [gentamycin metabolic process]
GO:1901652 [response to peptide]
GO:1901684 [arsenate ion transmembrane transport]
GO:2000120 [positive regulation of sodium-dependent phosphate transport]
GO:2000187 [positive regulation of phosphate transmembrane transport]
Show all
 639 aa
68.9 kDa 		No 9
SLC34A1-002
ENSP00000423022
ENST00000512593
Q06495 [Direct mapping]
Sodium-dependent phosphate transport protein 2A
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Plasma proteins
Disease related genes
Potential drug targets
Show all
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006811 [ion transport]
GO:0006814 [sodium ion transport]
GO:0006817 [phosphate ion transport]
GO:0010288 [response to lead ion]
GO:0015293 [symporter activity]
GO:0015321 [sodium-dependent phosphate transmembrane transporter activity]
GO:0016020 [membrane]
GO:0031526 [brush border membrane]
GO:0044267 [cellular protein metabolic process]
GO:0044341 [sodium-dependent phosphate transport]
GO:0046686 [response to cadmium ion]
GO:0046689 [response to mercury ion]
GO:0055062 [phosphate ion homeostasis]
GO:0055085 [transmembrane transport]
Show all
 340 aa
36.6 kDa 		No 3
SLC34A1-005
ENSP00000423733
ENST00000504577
D6RCE5 [Direct mapping]
Sodium-dependent phosphate transport protein 2A
Show all
Predicted intracellular proteins
Show all
GO:0005886 [plasma membrane]
GO:0015321 [sodium-dependent phosphate transmembrane transporter activity]
GO:0044341 [sodium-dependent phosphate transport]
Show all
 109 aa
11.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.