Expression of F12 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Coagulation factor XII (Hageman factor)

Protein class

Candidate cardiovascular disease genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA003825

GENE INFORMATION
Gene name	F12
Synonyms
Description	Coagulation factor XII (Hageman factor) (HGNC Symbol)
Entrez gene summary	This gene encodes coagulation factor XII which circulates in blood as a zymogen. This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain. The heavy chain contains two fibronectin-type domains, two epidermal growth factor (EGF)-like domains, a kringle domain and a proline-rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. It activates coagulation factors VII and XI. Defects in this gene do not cause any clinical symptoms and the sole effect is that whole-blood clotting time is prolonged. [provided by RefSeq, Jul 2008]
Chromosome	5
Cytoband	q35.3
Chromosome location (bp)	177402140 - 177409576
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000131187 (version 83.38)
Entrez gene	2161
UniProt	P00748 (UniProt - Evidence at protein level)
neXtProt	NX_P00748
Antibodypedia	F12 antibodies

PROTEIN BROWSER

F12-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
F12-001 ENSP00000253496 ENST00000253496	P00748 [Direct mapping] Coagulation factor XII Coagulation factor XIIa heavy chain Beta-factor XIIa part 1 Coagulation factor XIIa light chain Show all	Enzymes ENZYME proteins Hydrolases Peptidases Serine-type peptidases SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Candidate cardiovascular disease genes Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002353 [plasma kallikrein-kinin cascade] GO:0002542 [Factor XII activation] GO:0004252 [serine-type endopeptidase activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005886 [plasma membrane] GO:0006508 [proteolysis] GO:0007596 [blood coagulation] GO:0007597 [blood coagulation, intrinsic pathway] GO:0008233 [peptidase activity] GO:0010756 [positive regulation of plasminogen activation] GO:0016485 [protein processing] GO:0016540 [protein autoprocessing] GO:0030193 [regulation of blood coagulation] GO:0030194 [positive regulation of blood coagulation] GO:0031638 [zymogen activation] GO:0042730 [fibrinolysis] GO:0045087 [innate immune response] GO:0051787 [misfolded protein binding] GO:0051788 [response to misfolded protein] GO:0051919 [positive regulation of fibrinolysis] GO:0070062 [extracellular exosome] Show all	615 aa 67.8 kDa	Yes	0