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TRAF3

CANCER ATLAS

Gene description

 TNF receptor-associated factor 3

Protein class

 Cancer-related genes, Disease related genes, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA002933

GENE INFORMATION

Gene name

 TRAF3 (HGNC Symbol)

Synonyms

 CAP-1, CD40bp, CRAF1, LAP1

Description

 TNF receptor-associated factor 3 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from, members of the TNF receptor (TNFR) superfamily. This protein participates in the signal transduction of CD40, a TNFR family member important for the activation of the immune response. This protein is found to be a critical component of the lymphotoxin-beta receptor (LTbetaR) signaling complex, which induces NF-kappaB activation and cell death initiated by LTbeta ligation. Epstein-Barr virus encoded latent infection membrane protein-1 (LMP1) can interact with this and several other members of the TRAF family, which may be essential for the oncogenic effects of LMP1. Several alternatively spliced transcript variants encoding three distinct isoforms have been reported. [provided by RefSeq, Dec 2010]

Chromosome

 14

Cytoband

 q32.32

Chromosome location (bp)

 102777476 - 102911500

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000131323 (version 83.38)

Entrez gene

 7187

UniProt

 Q13114 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13114

Antibodypedia

 TRAF3 antibodies

PROTEIN BROWSER
TRAF3-001
TRAF3-002
TRAF3-004
TRAF3-005
TRAF3-006
TRAF3-008
TRAF3-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TRAF3-001
ENSP00000454207
ENST00000560371
Q13114 [Direct mapping]
TNF receptor-associated factor 3
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001817 [regulation of cytokine production]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0004871 [signal transducer activity]
GO:0005164 [tumor necrosis factor receptor binding]
GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0005768 [endosome]
GO:0005829 [cytosol]
GO:0006915 [apoptotic process]
GO:0007165 [signal transduction]
GO:0008270 [zinc ion binding]
GO:0009898 [cytoplasmic side of plasma membrane]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0019901 [protein kinase binding]
GO:0019903 [protein phosphatase binding]
GO:0030162 [regulation of proteolysis]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031996 [thioesterase binding]
GO:0032088 [negative regulation of NF-kappaB transcription factor activity]
GO:0032480 [negative regulation of type I interferon production]
GO:0032648 [regulation of interferon-beta production]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0035631 [CD40 receptor complex]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0042981 [regulation of apoptotic process]
GO:0045087 [innate immune response]
GO:0050688 [regulation of defense response to virus]
Show all
 568 aa
64.5 kDa 		No 0
TRAF3-002
ENSP00000445998
ENST00000539721
Q13114 [Direct mapping]
TNF receptor-associated factor 3
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001817 [regulation of cytokine production]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0004871 [signal transducer activity]
GO:0005164 [tumor necrosis factor receptor binding]
GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0005768 [endosome]
GO:0005829 [cytosol]
GO:0006915 [apoptotic process]
GO:0007165 [signal transduction]
GO:0008270 [zinc ion binding]
GO:0009898 [cytoplasmic side of plasma membrane]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0019903 [protein phosphatase binding]
GO:0030162 [regulation of proteolysis]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031996 [thioesterase binding]
GO:0032088 [negative regulation of NF-kappaB transcription factor activity]
GO:0032480 [negative regulation of type I interferon production]
GO:0032648 [regulation of interferon-beta production]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0035631 [CD40 receptor complex]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0042981 [regulation of apoptotic process]
GO:0045087 [innate immune response]
GO:0050688 [regulation of defense response to virus]
Show all
 485 aa
55.3 kDa 		No 0
TRAF3-004
ENSP00000332468
ENST00000351691
A6NHG8 [Direct mapping]
TNF receptor-associated factor 3
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0007165 [signal transduction]
GO:0008270 [zinc ion binding]
GO:0016567 [protein ubiquitination]
GO:0042981 [regulation of apoptotic process]
Show all
 543 aa
61.8 kDa 		No 0
TRAF3-005
ENSP00000376500
ENST00000392745
Q13114 [Direct mapping]
TNF receptor-associated factor 3
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001817 [regulation of cytokine production]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0004871 [signal transducer activity]
GO:0005164 [tumor necrosis factor receptor binding]
GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0005768 [endosome]
GO:0005829 [cytosol]
GO:0006915 [apoptotic process]
GO:0007165 [signal transduction]
GO:0008270 [zinc ion binding]
GO:0009898 [cytoplasmic side of plasma membrane]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0019903 [protein phosphatase binding]
GO:0030162 [regulation of proteolysis]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031996 [thioesterase binding]
GO:0032088 [negative regulation of NF-kappaB transcription factor activity]
GO:0032480 [negative regulation of type I interferon production]
GO:0032648 [regulation of interferon-beta production]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0035631 [CD40 receptor complex]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0042981 [regulation of apoptotic process]
GO:0045087 [innate immune response]
GO:0050688 [regulation of defense response to virus]
Show all
 568 aa
64.5 kDa 		No 0
TRAF3-006
ENSP00000453623
ENST00000560463
H0YMI8 [Direct mapping]
TNF receptor-associated factor 3
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0008270 [zinc ion binding]
GO:0046872 [metal ion binding]
Show all
 94 aa
10.3 kDa 		No 0
TRAF3-008
ENSP00000453032
ENST00000559734
H0YL26 [Direct mapping]
TNF receptor-associated factor 3
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0008270 [zinc ion binding]
GO:0016567 [protein ubiquitination]
Show all
 290 aa
33.6 kDa 		No 0
TRAF3-201
ENSP00000328003
ENST00000347662
A6NHG8 [Direct mapping]
TNF receptor-associated factor 3
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0007165 [signal transduction]
GO:0008270 [zinc ion binding]
GO:0016567 [protein ubiquitination]
GO:0042981 [regulation of apoptotic process]
Show all
 543 aa
61.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.