Expression of MRPS25 in cancer - Summary

CANCER ATLAS

Gene description

Mitochondrial ribosomal protein S25

Protein class

Predicted intracellular proteins, Ribosomal proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA043490

GENE INFORMATION
Gene name	MRPS25 (HGNC Symbol)
Synonyms	DKFZp313H0817, FLJ00023, MRP-S25, RPMS25
Description	Mitochondrial ribosomal protein S25 (HGNC Symbol)
Entrez gene summary	Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. A pseudogene corresponding to this gene is found on chromosome 4. [provided by RefSeq, Jul 2008]
Chromosome	3
Cytoband	p25.1
Chromosome location (bp)	15042460 - 15065335
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000131368 (version 83.38)
Entrez gene	64432
UniProt	P82663 (UniProt - Evidence at protein level)
neXtProt	NX_P82663
Antibodypedia	MRPS25 antibodies

PROTEIN BROWSER

MRPS25-001	MRPS25-002	MRPS25-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MRPS25-001 ENSP00000253686 ENST00000253686	P82663 [Direct mapping] 28S ribosomal protein S25, mitochondrial Show all	Ribosomal proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003735 [structural constituent of ribosome] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005840 [ribosome] GO:0006996 [organelle organization] GO:0032543 [mitochondrial translation] GO:0070124 [mitochondrial translational initiation] GO:0070125 [mitochondrial translational elongation] GO:0070126 [mitochondrial translational termination] Show all	173 aa 20.1 kDa	No	0
MRPS25-002 ENSP00000407733 ENST00000444840	P82663 [Direct mapping] 28S ribosomal protein S25, mitochondrial Show all	Ribosomal proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003735 [structural constituent of ribosome] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005840 [ribosome] GO:0006996 [organelle organization] GO:0032543 [mitochondrial translation] GO:0070124 [mitochondrial translational initiation] GO:0070125 [mitochondrial translational elongation] GO:0070126 [mitochondrial translational termination] Show all	129 aa 15 kDa	No	0
MRPS25-003 ENSP00000390882 ENST00000449354	P82663 [Direct mapping] 28S ribosomal protein S25, mitochondrial Show all	Ribosomal proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003735 [structural constituent of ribosome] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005840 [ribosome] GO:0006996 [organelle organization] GO:0032543 [mitochondrial translation] GO:0070124 [mitochondrial translational initiation] GO:0070125 [mitochondrial translational elongation] GO:0070126 [mitochondrial translational termination] Show all	145 aa 16.6 kDa	No	0