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RBSN

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GENERAL INFORMATION

Gene name

 RBSN

Gene description

 Rabenosyn, RAB effector

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to vesicles.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Vesicles (validated)

DATA RELIABILITY

Reliability score

 Validated based on 1 antibody.
HPA044878
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to vesicles.

Main location

 Vesicles (validated)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA044878 A-431 Vesicles
HPA044878 U-2 OS Vesicles
HPA044878 U-251 MG Vesicles

GENE INFORMATION

Gene name

 RBSN (HGNC Symbol)

Synonyms

 ZFYVE20

Description

 Rabenosyn, RAB effector (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that belongs to the FYVE zinc finger family of proteins. The encoded protein interacts with Ras-related proteins that regulate membrane trafficking. A missense mutation in this gene is associated with a defect in the early endocytic pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]

Chromosome

 3

Cytoband

 p25.1

Chromosome location (bp)

 15070073 - 15099163

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000131381 (version 83.38)

Entrez gene

 64145

UniProt

 Q9H1K0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9H1K0

Antibodypedia

 RBSN antibodies

PROTEIN BROWSER
RBSN-001
RBSN-002
RBSN-005
RBSN-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RBSN-001
ENSP00000253699
ENST00000253699
Q9H1K0 [Direct mapping]
Rabenosyn-5
A0A024R2H4 [Target identity:100%; Query identity:100%]
Zinc finger, FYVE domain containing 20, isoform CRA_a
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000011 [vacuole inheritance]
GO:0005515 [protein binding]
GO:0005768 [endosome]
GO:0005886 [plasma membrane]
GO:0006895 [Golgi to endosome transport]
GO:0006896 [Golgi to vacuole transport]
GO:0006897 [endocytosis]
GO:0007596 [blood coagulation]
GO:0008270 [zinc ion binding]
GO:0010008 [endosome membrane]
GO:0010009 [cytoplasmic side of endosome membrane]
GO:0015031 [protein transport]
GO:0016197 [endosomal transport]
GO:0017137 [Rab GTPase binding]
GO:0031901 [early endosome membrane]
GO:0034058 [endosomal vesicle fusion]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045324 [late endosome to vacuole transport]
GO:0046872 [metal ion binding]
GO:0070062 [extracellular exosome]
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 784 aa
88.9 kDa 		No 0
RBSN-002
ENSP00000422551
ENST00000476527
Q9H1K0 [Direct mapping]
Rabenosyn-5
A0A024R2H4 [Target identity:100%; Query identity:100%]
Zinc finger, FYVE domain containing 20, isoform CRA_a
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000011 [vacuole inheritance]
GO:0005515 [protein binding]
GO:0005768 [endosome]
GO:0005886 [plasma membrane]
GO:0006895 [Golgi to endosome transport]
GO:0006896 [Golgi to vacuole transport]
GO:0006897 [endocytosis]
GO:0007596 [blood coagulation]
GO:0008270 [zinc ion binding]
GO:0010008 [endosome membrane]
GO:0010009 [cytoplasmic side of endosome membrane]
GO:0015031 [protein transport]
GO:0016197 [endosomal transport]
GO:0017137 [Rab GTPase binding]
GO:0031901 [early endosome membrane]
GO:0034058 [endosomal vesicle fusion]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045324 [late endosome to vacuole transport]
GO:0046872 [metal ion binding]
GO:0070062 [extracellular exosome]
Show all
 784 aa
88.9 kDa 		No 0
RBSN-005
ENSP00000387724
ENST00000449050
C9JZZ1 [Direct mapping]
Protein RBSN
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000011 [vacuole inheritance]
GO:0006895 [Golgi to endosome transport]
GO:0006896 [Golgi to vacuole transport]
GO:0006897 [endocytosis]
GO:0010009 [cytoplasmic side of endosome membrane]
GO:0017137 [Rab GTPase binding]
GO:0034058 [endosomal vesicle fusion]
GO:0045324 [late endosome to vacuole transport]
GO:0046872 [metal ion binding]
Show all
 88 aa
10.1 kDa 		No 0
RBSN-010
ENSP00000427038
ENST00000507357
D6RD50 [Direct mapping]
Rabenosyn-5
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000011 [vacuole inheritance]
GO:0006895 [Golgi to endosome transport]
GO:0006896 [Golgi to vacuole transport]
GO:0006897 [endocytosis]
GO:0010009 [cytoplasmic side of endosome membrane]
GO:0017137 [Rab GTPase binding]
GO:0034058 [endosomal vesicle fusion]
GO:0045324 [late endosome to vacuole transport]
GO:0046872 [metal ion binding]
Show all
 41 aa
4.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.