Expression of KCNC3 in cancer - Summary

CANCER ATLAS

Gene description

Potassium channel, voltage gated Shaw related subfamily C, member 3

Protein class

Disease related genes, FDA approved drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters, Voltage-gated ion channels

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Testis cancer

STAINING SUMMARY

HPA018041

GENE INFORMATION
Gene name	KCNC3 (HGNC Symbol)
Synonyms	Kv3.3, SCA13
Description	Potassium channel, voltage gated Shaw related subfamily C, member 3 (HGNC Symbol)
Entrez gene summary	The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to one of these subfamilies, namely the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. Alternate splicing results in several transcript variants. [provided by RefSeq, Mar 2014]
Chromosome	19
Cytoband	q13.33
Chromosome location (bp)	50311937 - 50333515
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000131398 (version 83.38)
Entrez gene	3748
UniProt	Q14003 (UniProt - Evidence at protein level)
neXtProt	NX_Q14003
Antibodypedia	KCNC3 antibodies

PROTEIN BROWSER

KCNC3-002	KCNC3-004	KCNC3-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KCNC3-002 ENSP00000366158 ENST00000376959	E7ETH1 [Direct mapping] Potassium voltage-gated channel subfamily C member 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0005251 [delayed rectifier potassium channel activity] GO:0005515 [protein binding] GO:0006811 [ion transport] GO:0008076 [voltage-gated potassium channel complex] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034765 [regulation of ion transmembrane transport] GO:0051260 [protein homooligomerization] GO:0055085 [transmembrane transport] GO:0071805 [potassium ion transmembrane transport] Show all	728 aa 77.5 kDa	No	6
KCNC3-004 ENSP00000432438 ENST00000474951	E9PQY4 [Direct mapping] Potassium voltage-gated channel subfamily C member 3 Show all	Predicted intracellular proteins Show all	GO:0005251 [delayed rectifier potassium channel activity] GO:0016021 [integral component of membrane] GO:0071805 [potassium ion transmembrane transport] Show all	44 aa 4.8 kDa	No	0
KCNC3-005 ENSP00000434241 ENST00000477616	Q14003 [Direct mapping] Potassium voltage-gated channel subfamily C member 3 Show all	Transporters Transporter channels and pores Voltage-gated ion channels Voltage-Gated Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs Show all	GO:0005216 [ion channel activity] GO:0005249 [voltage-gated potassium channel activity] GO:0005251 [delayed rectifier potassium channel activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006811 [ion transport] GO:0007268 [synaptic transmission] GO:0008076 [voltage-gated potassium channel complex] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030673 [axolemma] GO:0031594 [neuromuscular junction] GO:0032590 [dendrite membrane] GO:0032809 [neuronal cell body membrane] GO:0034765 [regulation of ion transmembrane transport] GO:0043679 [axon terminus] GO:0046928 [regulation of neurotransmitter secretion] GO:0051260 [protein homooligomerization] GO:0051262 [protein tetramerization] GO:0055085 [transmembrane transport] GO:0071805 [potassium ion transmembrane transport] Show all	757 aa 80.6 kDa	No	6