Expression of MGAT1 in cancer - Summary

CANCER ATLAS

Gene description

Mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase

Protein class

Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA017432

GENE INFORMATION
Gene name	MGAT1 (HGNC Symbol)
Synonyms	GLCNAC-TI, GLYT1, GNT-1, MGAT
Description	Mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase (HGNC Symbol)
Entrez gene summary	There are believed to be over 100 different glycosyltransferases involved in the synthesis of protein-bound and lipid-bound oligosaccharides. UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I is a medial-Golgi enzyme essential for the synthesis of hybrid and complex N-glycans. The protein, encoded by a single exon, shows typical features of a type II transmembrane protein. The protein is believed to be essential for normal embryogenesis. Several variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	5
Cytoband	q35.3
Chromosome location (bp)	180784782 - 180815652
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000131446 (version 83.38)
Entrez gene	4245
UniProt	P26572 (UniProt - Evidence at protein level)
neXtProt	NX_P26572
Antibodypedia	MGAT1 antibodies

PROTEIN BROWSER

MGAT1-001	MGAT1-003	MGAT1-004	MGAT1-007	MGAT1-009	MGAT1-011	MGAT1-019	MGAT1-022	MGAT1-023	MGAT1-024	MGAT1-025	MGAT1-026	MGAT1-027	MGAT1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MGAT1-001 ENSP00000332073 ENST00000333055	P26572 [Direct mapping] Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase Show all	Enzymes ENZYME proteins Transferases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0001701 [in utero embryonic development] GO:0003827 [alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity] GO:0005975 [carbohydrate metabolic process] GO:0006049 [UDP-N-acetylglucosamine catabolic process] GO:0006486 [protein glycosylation] GO:0008375 [acetylglucosaminyltransferase activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0046872 [metal ion binding] GO:0070062 [extracellular exosome] GO:1903561 [extracellular vesicle] Show all	445 aa 50.9 kDa	No	0
MGAT1-003 ENSP00000404718 ENST00000446023	P26572 [Direct mapping] Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase Show all	Enzymes ENZYME proteins Transferases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0003827 [alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity] GO:0005975 [carbohydrate metabolic process] GO:0006486 [protein glycosylation] GO:0008375 [acetylglucosaminyltransferase activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0046872 [metal ion binding] GO:0070062 [extracellular exosome] GO:1903561 [extracellular vesicle] Show all	445 aa 50.9 kDa	No	0
MGAT1-004 ENSP00000402838 ENST00000427865	P26572 [Direct mapping] Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase Show all	Enzymes ENZYME proteins Transferases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0003827 [alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity] GO:0005975 [carbohydrate metabolic process] GO:0006486 [protein glycosylation] GO:0008375 [acetylglucosaminyltransferase activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0046872 [metal ion binding] GO:0070062 [extracellular exosome] GO:1903561 [extracellular vesicle] Show all	445 aa 50.9 kDa	No	0
MGAT1-007 ENSP00000311888 ENST00000307826	P26572 [Direct mapping] Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase Show all	Enzymes ENZYME proteins Transferases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0003827 [alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity] GO:0005975 [carbohydrate metabolic process] GO:0006486 [protein glycosylation] GO:0008375 [acetylglucosaminyltransferase activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0046872 [metal ion binding] GO:0070062 [extracellular exosome] GO:1903561 [extracellular vesicle] Show all	445 aa 50.9 kDa	No	0
MGAT1-009 ENSP00000421738 ENST00000514438	D6RAK2 [Direct mapping] Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006486 [protein glycosylation] GO:0008375 [acetylglucosaminyltransferase activity] GO:0016021 [integral component of membrane] Show all	105 aa 11.3 kDa	No	0
MGAT1-011 ENSP00000423401 ENST00000513431	D6RA48 [Direct mapping] Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006486 [protein glycosylation] GO:0008375 [acetylglucosaminyltransferase activity] GO:0016021 [integral component of membrane] Show all	95 aa 10.3 kDa	No	0
MGAT1-019 ENSP00000425988 ENST00000506889	D6RHZ8 [Direct mapping] Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006486 [protein glycosylation] GO:0008375 [acetylglucosaminyltransferase activity] GO:0016021 [integral component of membrane] Show all	154 aa 16.7 kDa	No	0
MGAT1-022 ENSP00000422588 ENST00000502678	D6RBS3 [Direct mapping] Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006486 [protein glycosylation] GO:0008375 [acetylglucosaminyltransferase activity] GO:0016021 [integral component of membrane] Show all	103 aa 11.1 kDa	No	0
MGAT1-023 ENSP00000424382 ENST00000514283	D6RB69 [Direct mapping] Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006486 [protein glycosylation] GO:0008375 [acetylglucosaminyltransferase activity] GO:0016021 [integral component of membrane] Show all	127 aa 13.8 kDa	No	0
MGAT1-024 ENSP00000427116 ENST00000512695	D6RD15 [Direct mapping] Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006486 [protein glycosylation] GO:0008375 [acetylglucosaminyltransferase activity] GO:0016021 [integral component of membrane] Show all	115 aa 12.4 kDa	No	0
MGAT1-025 ENSP00000422906 ENST00000506269	D6R9U2 [Direct mapping] Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006486 [protein glycosylation] GO:0008375 [acetylglucosaminyltransferase activity] GO:0016021 [integral component of membrane] Show all	111 aa 11.9 kDa	No	0
MGAT1-026 ENSP00000427433 ENST00000507384	D6RIS2 [Direct mapping] Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	34 aa 3.9 kDa	No	1
MGAT1-027 ENSP00000424891 ENST00000504671	D6RF69 [Direct mapping] Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006486 [protein glycosylation] GO:0008375 [acetylglucosaminyltransferase activity] GO:0016021 [integral component of membrane] Show all	199 aa 22 kDa	No	0
MGAT1-201 ENSP00000377010 ENST00000393340	P26572 [Direct mapping] Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase Show all	Enzymes ENZYME proteins Transferases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0003827 [alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity] GO:0005975 [carbohydrate metabolic process] GO:0006486 [protein glycosylation] GO:0008375 [acetylglucosaminyltransferase activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0046872 [metal ion binding] GO:0070062 [extracellular exosome] GO:1903561 [extracellular vesicle] Show all	445 aa 50.9 kDa	No	0