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Several colorectal cancers showed moderate to strong immunoreactivity while cases of squamous cell carcinomas, ovarian cancers and malignant melanomas displayed moderate cytoplasmic and/or membranous immunoreactivity. Remaining malignant cells were in general weakly stained or negative.
GENE INFORMATION
Gene name
TRAF7 (HGNC Symbol)
Synonyms
DKFZp586I021, MGC7807, RFWD1, RNF119
Description
TNF receptor-associated factor 7, E3 ubiquitin protein ligase (HGNC Symbol)
Entrez gene summary
Tumor necrosis factor (TNF; see MIM 191160) receptor-associated factors, such as TRAF7, are signal transducers for members of the TNF receptor superfamily (see MIM 191190). TRAFs are composed of an N-terminal cysteine/histidine-rich region containing zinc RING and/or zinc finger motifs; a coiled-coil (leucine zipper) motif; and a homologous region that defines the TRAF family, the TRAF domain, which is involved in self-association and receptor binding.[supplied by OMIM, Apr 2004]
Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000151 [ubiquitin ligase complex] GO:0000185 [activation of MAPKKK activity] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006351 [transcription, DNA-templated] GO:0006915 [apoptotic process] GO:0008270 [zinc ion binding] GO:0016023 [cytoplasmic membrane-bounded vesicle] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] GO:0032880 [regulation of protein localization] GO:0033235 [positive regulation of protein sumoylation] GO:0043231 [intracellular membrane-bounded organelle] GO:0043410 [positive regulation of MAPK cascade] GO:0048471 [perinuclear region of cytoplasm] GO:0071354 [cellular response to interleukin-6] GO:2001235 [positive regulation of apoptotic signaling pathway]
Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Protein evidence (Ezkurdia et al 2014)
