Tissue expression of FMO5 - Summary - The Human Protein Atlas

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FMO5

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TISSUE

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CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	FMO5
Gene description	Flavin containing monooxygenase 5
Protein class	Cancer-related genes Enzymes Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (liver)
GTEx:	Tissue enhanced (stomach, liver)
FANTOM5:	Group enriched (liver, colon, small intestine, lung)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in several tissues most abundant in hepatocytes and gastrointestinal tract.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Supported based on 1 antibody. HPA012373
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (liver)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (stomach, liver)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Group enriched (liver, colon, small intestine, lung)

GENE INFORMATION
Gene name	FMO5
Synonyms
Description	Flavin containing monooxygenase 5 (HGNC Symbol)
Entrez gene summary	Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009]
Chromosome	1
Cytoband	q21.1
Chromosome location (bp)	147175351 - 147243050
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000131781 (version 83.38)
Entrez gene	2330
UniProt	P49326 (UniProt - Evidence at protein level)
neXtProt	NX_P49326
Antibodypedia	FMO5 antibodies

PROTEIN BROWSER

FMO5-001	FMO5-004	FMO5-006	FMO5-007	FMO5-009	FMO5-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FMO5-001 ENSP00000254090 ENST00000254090	P49326 [Direct mapping] Dimethylaniline monooxygenase [N-oxide-forming] 5 A0A024QYY6 [Target identity:100%; Query identity:100%] Dimethylaniline monooxygenase [N-oxide-forming] Show all	Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004499 [N,N-dimethylaniline monooxygenase activity] GO:0005789 [endoplasmic reticulum membrane] GO:0008150 [biological_process] GO:0016021 [integral component of membrane] GO:0017144 [drug metabolic process] GO:0050660 [flavin adenine dinucleotide binding] GO:0050661 [NADP binding] GO:0055114 [oxidation-reduction process] Show all	533 aa 60.2 kDa	Yes	1
FMO5-004 ENSP00000358277 ENST00000369272	P49326 [Direct mapping] Dimethylaniline monooxygenase [N-oxide-forming] 5 Show all	Enzymes ENZYME proteins Oxidoreductases SPOCTOPUS predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004499 [N,N-dimethylaniline monooxygenase activity] GO:0005789 [endoplasmic reticulum membrane] GO:0008150 [biological_process] GO:0016021 [integral component of membrane] GO:0017144 [drug metabolic process] GO:0050660 [flavin adenine dinucleotide binding] GO:0050661 [NADP binding] GO:0055114 [oxidation-reduction process] Show all	285 aa 32.5 kDa	No	0
FMO5-006 ENSP00000432569 ENST00000533848	E9PQ84 [Direct mapping] Dimethylaniline monooxygenase [N-oxide-forming] 5 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004499 [N,N-dimethylaniline monooxygenase activity] GO:0017144 [drug metabolic process] GO:0050660 [flavin adenine dinucleotide binding] GO:0050661 [NADP binding] GO:0055114 [oxidation-reduction process] Show all	145 aa 16.6 kDa	Yes	0
FMO5-007 ENSP00000436429 ENST00000533174	E9PP51 [Direct mapping] Dimethylaniline monooxygenase [N-oxide-forming] 5 Show all	SPOCTOPUS predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004499 [N,N-dimethylaniline monooxygenase activity] GO:0017144 [drug metabolic process] GO:0050660 [flavin adenine dinucleotide binding] GO:0050661 [NADP binding] GO:0055114 [oxidation-reduction process] Show all	192 aa 21.9 kDa	No	0
FMO5-009 ENSP00000416011 ENST00000441068	P49326 [Direct mapping] Dimethylaniline monooxygenase [N-oxide-forming] 5 Show all	Enzymes ENZYME proteins Oxidoreductases MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0004499 [N,N-dimethylaniline monooxygenase activity] GO:0005789 [endoplasmic reticulum membrane] GO:0008150 [biological_process] GO:0016021 [integral component of membrane] GO:0017144 [drug metabolic process] GO:0050660 [flavin adenine dinucleotide binding] GO:0050661 [NADP binding] GO:0055114 [oxidation-reduction process] Show all	464 aa 52.5 kDa	No	0
FMO5-201 ENSP00000462062 ENST00000578284	P49326 [Direct mapping] Dimethylaniline monooxygenase [N-oxide-forming] 5 Show all	Enzymes ENZYME proteins Oxidoreductases MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004499 [N,N-dimethylaniline monooxygenase activity] GO:0005789 [endoplasmic reticulum membrane] GO:0008150 [biological_process] GO:0016021 [integral component of membrane] GO:0017144 [drug metabolic process] GO:0050660 [flavin adenine dinucleotide binding] GO:0050661 [NADP binding] GO:0055114 [oxidation-reduction process] Show all	464 aa 52.5 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.