Tissue expression of THAP1 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	THAP1
Gene description	THAP domain containing, apoptosis associated protein 1
Protein class	Disease related genes Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Mixed
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Mixed
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	THAP1 (HGNC Symbol)
Synonyms	4833431A01Rik, DYT6, FLJ10477
Description	THAP domain containing, apoptosis associated protein 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene contains a THAP domain, a conserved DNA-binding domain. This protein colocalizes with the apoptosis response protein PAWR/PAR-4 in promyelocytic leukemia (PML) nuclear bodies, and functions as a proapoptotic factor that links PAWR to PML nuclear bodies. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Chromosome	8
Cytoband	p11.21
Chromosome location (bp)	42836674 - 42843325
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000131931 (version 83.38)
Entrez gene	55145
UniProt	Q9NVV9 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NVV9
Antibodypedia	THAP1 antibodies

PROTEIN BROWSER

THAP1-001	THAP1-002	THAP1-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
THAP1-001 ENSP00000254250 ENST00000254250	Q9NVV9 [Direct mapping] THAP domain-containing protein 1 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Disease related genes Show all	GO:0001935 [endothelial cell proliferation] GO:0003676 [nucleic acid binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007049 [cell cycle] GO:0007346 [regulation of mitotic cell cycle] GO:0008270 [zinc ion binding] GO:0016605 [PML body] GO:0042802 [identical protein binding] GO:0043565 [sequence-specific DNA binding] Show all	213 aa 24.9 kDa	No	0
THAP1-002 ENSP00000344966 ENST00000345117	Q9NVV9 [Direct mapping] THAP domain-containing protein 1 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Disease related genes Show all	GO:0001935 [endothelial cell proliferation] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007049 [cell cycle] GO:0007346 [regulation of mitotic cell cycle] GO:0008270 [zinc ion binding] GO:0016605 [PML body] GO:0042802 [identical protein binding] GO:0043565 [sequence-specific DNA binding] Show all	53 aa 6.5 kDa	No	0
THAP1-004 ENSP00000433912 ENST00000529779	E9PIS9 [Direct mapping] THAP domain-containing protein 1 Show all	Predicted intracellular proteins Show all	GO:0003676 [nucleic acid binding] Show all	118 aa 13.9 kDa	No	0