Expression of FBXW9 in cancer - Summary

CANCER ATLAS

Gene description

F-box and WD repeat domain containing 9

Protein class

Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA042087

GENE INFORMATION
Gene name	FBXW9 (HGNC Symbol)
Synonyms	Fbw9, MGC10870
Description	F-box and WD repeat domain containing 9 (HGNC Symbol)
Entrez gene summary	Members of the F-box protein family, such as FBXW9, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603034), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
Chromosome	19
Cytoband	p13.13
Chromosome location (bp)	12688053 - 12696643
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000132004 (version 83.38)
Entrez gene	84261
UniProt	Q5XUX1 (UniProt - Evidence at protein level)
neXtProt	NX_Q5XUX1
Antibodypedia	FBXW9 antibodies

PROTEIN BROWSER

FBXW9-001	FBXW9-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FBXW9-001 ENSP00000376945 ENST00000393261	Q5XUX1 [Direct mapping] F-box/WD repeat-containing protein 9 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0031146 [SCF-dependent proteasomal ubiquitin-dependent protein catabolic process] Show all	458 aa 50.8 kDa	No	0
FBXW9-003 ENSP00000465387 ENST00000587955	Q5XUX1 [Direct mapping] F-box/WD repeat-containing protein 9 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0031146 [SCF-dependent proteasomal ubiquitin-dependent protein catabolic process] Show all	478 aa 53 kDa	No	0