We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Most cancer tissues showed weak to moderate nuclear positivity. Rare cases of carcinoid, melanomas and skin cancers were strongly stained. Several cases of lymphomas and renal cancers were negative.
GENE INFORMATION
Gene name
RFX1 (HGNC Symbol)
Synonyms
EF-C
Description
Regulatory factor X, 1 (influences HLA class II expression) (HGNC Symbol)
Entrez gene summary
This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X2, X3, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a heterodimer with RFX family members X2, X3, and X5, but not with X4. This protein binds to the X-boxes of MHC class II genes and is essential for their expression. Also, it can bind to an inverted repeat that is required for expression of hepatitis B virus genes. [provided by RefSeq, Jul 2008]
P22670 [Direct mapping] MHC class II regulatory factor RFX1
Show all
SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Transcription factors Helix-turn-helix domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0003677 [DNA binding] GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006955 [immune response] GO:0043231 [intracellular membrane-bounded organelle]
