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Most cancers showed moderate to strong cytoplasmic and/or membranous staining. Several squamous cell carcinomas displayed strong nuclear and cytoplasmic staining. Hepatocellular carcinomas along with most gliomas, melanomas, lymphomas, renal and testicular cancers were weakly stained or negative.
Most cancer cells displayed weak to moderate cytoplasmic immunoreactivity. Several endometrial, testicular and renal cancers were negative.
GENE INFORMATION
Gene name
TRIM21 (HGNC Symbol)
Synonyms
RNF81, Ro/SSA, RO52, SSA1
Description
Tripartite motif containing 21 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The encoded protein is part of the RoSSA ribonucleoprotein, which includes a single polypeptide and one of four small RNA molecules. The RoSSA particle localizes to both the cytoplasm and the nucleus. RoSSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus. Alternatively spliced transcript variants for this gene have been described but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008]