Tissue expression of FCRLA - Summary - The Human Protein Atlas

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FCRLA

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TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	FCRLA
Gene description	Fc receptor-like A
Protein class	Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	12
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Group enriched (tonsil, lymph node, spleen, appendix)
GTEx:	Group enriched (spleen, small intestine)
FANTOM5:	Group enriched (tonsil, appendix, spleen, lymph node)

Protein evidence

Evidence at protein level

Protein expression

High membranous expression in a subset of lymphocytes.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Supported based on 1 antibody. CAB016545
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Group enriched (tonsil, lymph node, spleen, appendix)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Group enriched (spleen, small intestine)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Group enriched (tonsil, appendix, spleen, lymph node)

GENE INFORMATION
Gene name	FCRLA (HGNC Symbol)
Synonyms	FCRL, FCRLa, FCRLb, FCRLc1, FCRLc2, FCRLd, FCRLe, FCRLM1, FCRLX, FREB, MGC4595
Description	Fc receptor-like A (HGNC Symbol)
Entrez gene summary	This gene encodes a protein similar to receptors for the Fc fragment of gamma immunoglobulin (IgG). These receptors, referred to as FCGRs, mediate the destruction of IgG-coated antigens and of cells induced by antibodies. This encoded protein is selectively expressed in B cells, and may be involved in their development. This protein may also be involved in the development of lymphomas. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
Chromosome	1
Cytoband	q23.3
Chromosome location (bp)	161706972 - 161714352
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000132185 (version 83.38)
Entrez gene	84824
UniProt	Q7L513 (UniProt - Evidence at protein level)
neXtProt	NX_Q7L513
Antibodypedia	FCRLA antibodies

PROTEIN BROWSER

FCRLA-001	FCRLA-002	FCRLA-003	FCRLA-004	FCRLA-005	FCRLA-006	FCRLA-007	FCRLA-201	FCRLA-202	FCRLA-203	FCRLA-204	FCRLA-205

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FCRLA-001 ENSP00000236938 ENST00000236938	Q7L513 [Direct mapping] Fc receptor-like A Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005737 [cytoplasm] GO:0030154 [cell differentiation] Show all	376 aa 40.7 kDa	No	0
FCRLA-002 ENSP00000309596 ENST00000309691	Q7L513 [Direct mapping] Fc receptor-like A Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005737 [cytoplasm] GO:0030154 [cell differentiation] Show all	270 aa 29.3 kDa	Yes	0
FCRLA-003 ENSP00000356930 ENST00000367953	Q7L513 [Direct mapping] Fc receptor-like A Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005737 [cytoplasm] GO:0030154 [cell differentiation] Show all	365 aa 39.4 kDa	Yes	0
FCRLA-004 ENSP00000356934 ENST00000367957	Q7L513 [Direct mapping] Fc receptor-like A Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005737 [cytoplasm] GO:0030154 [cell differentiation] Show all	236 aa 25.4 kDa	No	1
FCRLA-005 ENSP00000294796 ENST00000294796	Q7L513 [Direct mapping] Fc receptor-like A Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005737 [cytoplasm] GO:0030154 [cell differentiation] Show all	225 aa 24.1 kDa	Yes	0
FCRLA-006 ENSP00000356927 ENST00000367950	Q5VXA5 [Direct mapping] Fc receptor-like A Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		152 aa 16.2 kDa	No	0
FCRLA-007 ENSP00000294798 ENST00000349527	Q7L513 [Direct mapping] Fc receptor-like A Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005737 [cytoplasm] GO:0030154 [cell differentiation] Show all	264 aa 28.4 kDa	Yes	0
FCRLA-201 ENSP00000344808 ENST00000350710	Q7L513 [Direct mapping] Fc receptor-like A Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005576 [extracellular region] GO:0005737 [cytoplasm] GO:0030154 [cell differentiation] Show all	141 aa 14.8 kDa	Yes	0
FCRLA-202 ENSP00000356926 ENST00000367949	Q7L513 [Direct mapping] Fc receptor-like A Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005576 [extracellular region] GO:0005737 [cytoplasm] GO:0030154 [cell differentiation] Show all	192 aa 20.4 kDa	No	0
FCRLA-203 ENSP00000356936 ENST00000367959	Q7L513 [Direct mapping] Fc receptor-like A Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005737 [cytoplasm] GO:0030154 [cell differentiation] Show all	382 aa 41.2 kDa	Yes	0
FCRLA-204 ENSP00000442870 ENST00000540521	Q7L513 [Direct mapping] Fc receptor-like A Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005737 [cytoplasm] GO:0030154 [cell differentiation] Show all	242 aa 25.9 kDa	Yes	0
FCRLA-205 ENSP00000439838 ENST00000546024	Q7L513 [Direct mapping] Fc receptor-like A Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005737 [cytoplasm] GO:0030154 [cell differentiation] Show all	287 aa 31 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.