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HSD17B7

GENERAL INFORMATION

Gene name

 HSD17B7

Gene description

 Hydroxysteroid (17-beta) dehydrogenase 7

Protein class

 Enzymes
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

 Membrane,Secreted

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Mixed
FANTOM5:Not detected

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA047496
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Adrenal gland

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Not detected

GENE INFORMATION

Gene name

 HSD17B7 (HGNC Symbol)

Synonyms

 PRAP, SDR37C1

Description

 Hydroxysteroid (17-beta) dehydrogenase 7 (HGNC Symbol)

Entrez gene summary

 HSD17B7 encodes an enzyme that functions both as a 17-beta-hydroxysteroid dehydrogenase (EC 1.1.1.62) in the biosynthesis of sex steroids and as a 3-ketosteroid reductase (EC 1.1.1.270) in the biosynthesis of cholesterol (Marijanovic et al., 2003 [PubMed 12829805]).[supplied by OMIM, May 2010]

Chromosome

 1

Cytoband

 q23.3

Chromosome location (bp)

 162790702 - 162812817

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000132196 (version 83.38)

Entrez gene

 51478

UniProt

 P56937 (UniProt - Evidence at protein level)

neXtProt

 NX_P56937

Antibodypedia

 HSD17B7 antibodies

PROTEIN BROWSER
HSD17B7-001
HSD17B7-005
HSD17B7-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HSD17B7-001
ENSP00000254521
ENST00000254521
P56937 [Direct mapping]
3-keto-steroid reductase
A0A024R913 [Target identity:100%; Query identity:100%]
HCG2024989, isoform CRA_a
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Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000253 [3-keto sterol reductase activity]
GO:0004303 [estradiol 17-beta-dehydrogenase activity]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0006695 [cholesterol biosynthetic process]
GO:0006703 [estrogen biosynthetic process]
GO:0008152 [metabolic process]
GO:0016021 [integral component of membrane]
GO:0016491 [oxidoreductase activity]
GO:0044281 [small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
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 341 aa
38.2 kDa 		Yes 1
HSD17B7-005
ENSP00000356892
ENST00000367915
Q5T249 [Direct mapping]
3-keto-steroid reductase; HCG2024989, isoform CRA_g
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008152 [metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
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 84 aa
9.1 kDa 		Yes 0
HSD17B7-007
ENSP00000356889
ENST00000367913
Q5T248 [Direct mapping]
3-keto-steroid reductase; HCG2024989, isoform CRA_e
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008152 [metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
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 111 aa
12.1 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.