Expression of ENOSF1 in cancer - Summary

CANCER ATLAS

Gene description

Enolase superfamily member 1

Protein class

Enzymes, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA047829

GENE INFORMATION
Gene name	ENOSF1 (HGNC Symbol)
Synonyms	HSRTSBETA, rTS, TYMSAS
Description	Enolase superfamily member 1 (HGNC Symbol)
Entrez gene summary	This gene was originally identified as a naturally occurring antisense transcript to the human thymidylate synthase gene. Alternate splice variants have been described, one of which (named rTSalpha) represents an alternate 3'UTR that is complementary to the 3'UTR and terminal intron of the thymidylate synthase (TS) RNA and down-regulates TS expression. Other transcript variants (rTSbeta and rTSgamma) do not overlap the TS locus. The function of this gene appears to be primarily to regulate expression of the TS locus both via the antisense transcript as well as through the encoded proteins. [provided by RefSeq, Mar 2010]
Chromosome	18
Cytoband	p11.32
Chromosome location (bp)	670324 - 712676
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000132199 (version 83.38)
Entrez gene	55556
UniProt	Q7L5Y1 (UniProt - Evidence at protein level)
neXtProt	NX_Q7L5Y1
Antibodypedia	ENOSF1 antibodies

PROTEIN BROWSER

ENOSF1-001	ENOSF1-002	ENOSF1-004	ENOSF1-016	ENOSF1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ENOSF1-001 ENSP00000251101 ENST00000251101	Q7L5Y1 [Direct mapping] Mitochondrial enolase superfamily member 1 Show all	Enzymes ENZYME proteins Lyases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0005575 [cellular_component] GO:0005739 [mitochondrion] GO:0009063 [cellular amino acid catabolic process] GO:0016853 [isomerase activity] GO:0044275 [cellular carbohydrate catabolic process] GO:0050023 [L-fuconate dehydratase activity] Show all	443 aa 49.8 kDa	No	0
ENOSF1-002 ENSP00000345974 ENST00000340116	Q7L5Y1 [Direct mapping] Mitochondrial enolase superfamily member 1 Show all	Enzymes ENZYME proteins Lyases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0005575 [cellular_component] GO:0005739 [mitochondrion] GO:0009063 [cellular amino acid catabolic process] GO:0016853 [isomerase activity] GO:0044275 [cellular carbohydrate catabolic process] GO:0050023 [L-fuconate dehydratase activity] Show all	450 aa 50.2 kDa	No	0
ENOSF1-004 ENSP00000463425 ENST00000580982	J3QL81 [Direct mapping] Mitochondrial enolase superfamily member 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0009063 [cellular amino acid catabolic process] Show all	367 aa 40.7 kDa	No	0
ENOSF1-016 ENSP00000473632 ENST00000583771	R4GNF8 [Direct mapping] Mitochondrial enolase superfamily member 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] Show all	98 aa 11.1 kDa	No	0
ENOSF1-201 ENSP00000373072 ENST00000383578	Q7L5Y1 [Direct mapping] Mitochondrial enolase superfamily member 1 Show all	Enzymes ENZYME proteins Lyases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0005575 [cellular_component] GO:0005739 [mitochondrion] GO:0009063 [cellular amino acid catabolic process] GO:0016853 [isomerase activity] GO:0044275 [cellular carbohydrate catabolic process] GO:0050023 [L-fuconate dehydratase activity] Show all	361 aa 41 kDa	No	0