Cell atlas - RAMP1 - The Human Protein Atlas

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RAMP1

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nuclear membrane
	Nucleoplasm

Human cell
	Nuclear membrane
	Nucleoplasm

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GENERAL INFORMATION
Gene name	RAMP1
Gene description	Receptor (G protein-coupled) activity modifying protein 1
Protein class	FDA approved drug targets Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nuclear membrane & nucleoplasm.
RNA cell category	Cell line enhanced (SH-SY5Y, PC-3, HDLM-2)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved), Nuclear membrane (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA057814
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (SH-SY5Y, PC-3, HDLM-2) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nuclear membrane & nucleoplasm.

Main location

Nucleoplasm (approved), Nuclear membrane (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA057814	A-431	Nucleoplasm	Intensity
	HPA057814	A-431	Nuclear membrane	Intensity
	HPA057814	PC-3	Nucleoplasm	Intensity
	HPA057814	PC-3	Nuclear membrane	Intensity
	HPA057814	U-2 OS	No staining

GENE INFORMATION
Gene name	RAMP1
Synonyms
Description	Receptor (G protein-coupled) activity modifying protein 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP1) protein, CRLR functions as a CGRP receptor. The RAMP1 protein is involved in the terminal glycosylation, maturation, and presentation of the CGRP receptor to the cell surface. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]
Chromosome	2
Cytoband	q37.3
Chromosome location (bp)	237858893 - 237912114
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000132329 (version 83.38)
Entrez gene	10267
UniProt	O60894 (UniProt - Evidence at protein level)
neXtProt	NX_O60894
Antibodypedia	RAMP1 antibodies

PROTEIN BROWSER

RAMP1-001	RAMP1-002	RAMP1-003	RAMP1-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RAMP1-001 ENSP00000254661 ENST00000254661	O60894 [Direct mapping] Receptor activity-modifying protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM FDA approved drug targets Biotech drugs Protein evidence (Kim et al 2014) Show all	GO:0001525 [angiogenesis] GO:0004872 [receptor activity] GO:0004948 [calcitonin receptor activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006816 [calcium ion transport] GO:0006886 [intracellular protein transport] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway] GO:0008565 [protein transporter activity] GO:0009986 [cell surface] GO:0015026 [coreceptor activity] GO:0015031 [protein transport] GO:0016021 [integral component of membrane] GO:0030819 [positive regulation of cAMP biosynthetic process] GO:0031623 [receptor internalization] GO:0031716 [calcitonin receptor binding] GO:0032870 [cellular response to hormone stimulus] GO:0043235 [receptor complex] GO:0060050 [positive regulation of protein glycosylation] GO:0072659 [protein localization to plasma membrane] Show all	148 aa 17 kDa	Yes	1
RAMP1-002 ENSP00000386046 ENST00000403885	E9PC20 [Direct mapping] Receptor activity-modifying protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005622 [intracellular] GO:0006886 [intracellular protein transport] GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway] GO:0008565 [protein transporter activity] GO:0016021 [integral component of membrane] Show all	126 aa 14.4 kDa	No	1
RAMP1-003 ENSP00000384688 ENST00000404910	E9PC20 [Direct mapping] Receptor activity-modifying protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005622 [intracellular] GO:0006886 [intracellular protein transport] GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway] GO:0008565 [protein transporter activity] GO:0016021 [integral component of membrane] Show all	126 aa 14.4 kDa	No	1
RAMP1-004 ENSP00000386720 ENST00000409726	E9PC20 [Direct mapping] Receptor activity-modifying protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005622 [intracellular] GO:0006886 [intracellular protein transport] GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway] GO:0008565 [protein transporter activity] GO:0016021 [integral component of membrane] Show all	126 aa 14.4 kDa	No	1

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.