Expression of SCLY in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Selenocysteine lyase

Protein class

Enzymes, Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA055760

GENE INFORMATION
Gene name	SCLY (HGNC Symbol)
Synonyms	SCL
Description	Selenocysteine lyase (HGNC Symbol)
Entrez gene summary	Selenocysteine lyase (SCLY; EC 4.4.1.16) catalyzes the pyridoxal 5-prime phosphate-dependent conversion of L-selenocysteine to L-alanine and elemental selenium (Mihara et al., 2000 [PubMed 10692412]).[supplied by OMIM, Mar 2008]
Chromosome	2
Cytoband	q37.3
Chromosome location (bp)	238060889 - 238099413
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000132330 (version 83.38)
Entrez gene	51540
UniProt	Q96I15 (UniProt - Evidence at protein level)
neXtProt	NX_Q96I15
Antibodypedia	SCLY antibodies

PROTEIN BROWSER

SCLY-001	SCLY-003	SCLY-006	SCLY-008	SCLY-011	SCLY-013	SCLY-017	SCLY-019	SCLY-020	SCLY-021

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SCLY-001 ENSP00000254663 ENST00000254663	A0A0A0MQU4 [Direct mapping] Selenocysteine lyase Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] Show all	453 aa 48.8 kDa	No	0
SCLY-003 ENSP00000387162 ENST00000409736	Q96I15 [Direct mapping] Selenocysteine lyase Show all	Enzymes ENZYME proteins Lyases Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005829 [cytosol] GO:0006520 [cellular amino acid metabolic process] GO:0009000 [selenocysteine lyase activity] GO:0016740 [transferase activity] Show all	317 aa 34 kDa	No	0
SCLY-006 ENSP00000414053 ENST00000450965	H7C3V9 [Direct mapping] Selenocysteine lyase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] Show all	241 aa 26.2 kDa	No	0
SCLY-008 ENSP00000414165 ENST00000413463	C9JNL5 [Direct mapping] Selenocysteine lyase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] Show all	171 aa 17.9 kDa	No	0
SCLY-011 ENSP00000416344 ENST00000412508	H7C4A1 [Direct mapping] Selenocysteine lyase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] Show all	196 aa 21.2 kDa	No	0
SCLY-013 ENSP00000404473 ENST00000416757	H7C280 [Direct mapping] Selenocysteine lyase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] Show all	151 aa 16.3 kDa	No	0
SCLY-017 ENSP00000401401 ENST00000433750	H7C1N7 [Direct mapping] Selenocysteine lyase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] Show all	122 aa 13.7 kDa	No	0
SCLY-019 ENSP00000402078 ENST00000431487	H7C1S7 [Direct mapping] Selenocysteine lyase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] Show all	168 aa 17.9 kDa	No	0
SCLY-020 ENSP00000404444 ENST00000437134	H7C277 [Direct mapping] Selenocysteine lyase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] Show all	251 aa 26.9 kDa	No	1
SCLY-021 ENSP00000405907 ENST00000440143	H7C2H3 [Direct mapping] Selenocysteine lyase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		59 aa 6.6 kDa	No	0