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Carcinoid, thyroid, several colorectal and urothelial cancers along with few testis, pancreas, cervical cancers and melanomas showed weak to moderate immunoreactivity. Remaining cancer tissues were negative.
Cancer cells displayed weak to moderate cytoplasmic immunoreactivity.
GENE INFORMATION
Gene name
PRKAA1 (HGNC Symbol)
Synonyms
AMPKa1
Description
Protein kinase, AMP-activated, alpha 1 catalytic subunit (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Q13131 [Direct mapping] 5'-AMP-activated protein kinase catalytic subunit alpha-1
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Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000187 [activation of MAPK activity] GO:0001666 [response to hypoxia] GO:0003682 [chromatin binding] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004679 [AMP-activated protein kinase activity] GO:0004691 [cAMP-dependent protein kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006006 [glucose metabolic process] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006468 [protein phosphorylation] GO:0006633 [fatty acid biosynthetic process] GO:0006695 [cholesterol biosynthetic process] GO:0007050 [cell cycle arrest] GO:0007165 [signal transduction] GO:0008022 [protein C-terminus binding] GO:0008284 [positive regulation of cell proliferation] GO:0008286 [insulin receptor signaling pathway] GO:0008610 [lipid biosynthetic process] GO:0009411 [response to UV] GO:0009631 [cold acclimation] GO:0010332 [response to gamma radiation] GO:0010467 [gene expression] GO:0010508 [positive regulation of autophagy] GO:0010628 [positive regulation of gene expression] GO:0014823 [response to activity] GO:0016055 [Wnt signaling pathway] GO:0016236 [macroautophagy] GO:0016324 [apical plasma membrane] GO:0019395 [fatty acid oxidation] GO:0019900 [kinase binding] GO:0031000 [response to caffeine] GO:0031588 [nucleotide-activated protein kinase complex] GO:0031669 [cellular response to nutrient levels] GO:0032007 [negative regulation of TOR signaling] GO:0033135 [regulation of peptidyl-serine phosphorylation] GO:0035174 [histone serine kinase activity] GO:0035404 [histone-serine phosphorylation] GO:0035556 [intracellular signal transduction] GO:0042149 [cellular response to glucose starvation] GO:0042542 [response to hydrogen peroxide] GO:0042593 [glucose homeostasis] GO:0042752 [regulation of circadian rhythm] GO:0043066 [negative regulation of apoptotic process] GO:0043234 [protein complex] GO:0045542 [positive regulation of cholesterol biosynthetic process] GO:0045821 [positive regulation of glycolytic process] GO:0046318 [negative regulation of glucosylceramide biosynthetic process] GO:0046872 [metal ion binding] GO:0047322 [[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity] GO:0048511 [rhythmic process] GO:0048643 [positive regulation of skeletal muscle tissue development] GO:0050321 [tau-protein kinase activity] GO:0050405 [[acetyl-CoA carboxylase] kinase activity] GO:0050995 [negative regulation of lipid catabolic process] GO:0051291 [protein heterooligomerization] GO:0055089 [fatty acid homeostasis] GO:0060627 [regulation of vesicle-mediated transport] GO:0070301 [cellular response to hydrogen peroxide] GO:0071361 [cellular response to ethanol] GO:0071380 [cellular response to prostaglandin E stimulus] GO:0071417 [cellular response to organonitrogen compound] GO:0071456 [cellular response to hypoxia] GO:1901563 [response to camptothecin] GO:2000505 [regulation of energy homeostasis] GO:2001274 [negative regulation of glucose import in response to insulin stimulus]
Q13131 [Direct mapping] 5'-AMP-activated protein kinase catalytic subunit alpha-1
Show all
Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000187 [activation of MAPK activity] GO:0001666 [response to hypoxia] GO:0003682 [chromatin binding] GO:0004672 [protein kinase activity] GO:0004679 [AMP-activated protein kinase activity] GO:0004691 [cAMP-dependent protein kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006468 [protein phosphorylation] GO:0006633 [fatty acid biosynthetic process] GO:0006695 [cholesterol biosynthetic process] GO:0007050 [cell cycle arrest] GO:0007165 [signal transduction] GO:0008286 [insulin receptor signaling pathway] GO:0008610 [lipid biosynthetic process] GO:0010332 [response to gamma radiation] GO:0010467 [gene expression] GO:0010508 [positive regulation of autophagy] GO:0010628 [positive regulation of gene expression] GO:0016055 [Wnt signaling pathway] GO:0016236 [macroautophagy] GO:0031588 [nucleotide-activated protein kinase complex] GO:0031669 [cellular response to nutrient levels] GO:0032007 [negative regulation of TOR signaling] GO:0035174 [histone serine kinase activity] GO:0035404 [histone-serine phosphorylation] GO:0035556 [intracellular signal transduction] GO:0042149 [cellular response to glucose starvation] GO:0042593 [glucose homeostasis] GO:0042752 [regulation of circadian rhythm] GO:0043066 [negative regulation of apoptotic process] GO:0045542 [positive regulation of cholesterol biosynthetic process] GO:0045821 [positive regulation of glycolytic process] GO:0046318 [negative regulation of glucosylceramide biosynthetic process] GO:0046872 [metal ion binding] GO:0047322 [[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity] GO:0048511 [rhythmic process] GO:0050321 [tau-protein kinase activity] GO:0050405 [[acetyl-CoA carboxylase] kinase activity] GO:0050995 [negative regulation of lipid catabolic process] GO:0055089 [fatty acid homeostasis] GO:2000505 [regulation of energy homeostasis]