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Moderate cytoplasmic staining with additional nuclear positivity in a few cases was observed in pancreatic cancer and several cases of malignant melanoma, colorectal, breast, ovarian and urothelial cancer. Remaining cancer tissues were in general weakly stained or negative.
GENE INFORMATION
Gene name
CARD6 (HGNC Symbol)
Synonyms
CINCIN1
Description
Caspase recruitment domain family, member 6 (HGNC Symbol)
Entrez gene summary
This gene encodes a protein that contains a caspase recruitment domain (CARD), an antiparallel six-helical bundle that mediates homotypic protein-protein interactions. The encoded protein is a microtubule-associated protein that has been shown to interact with receptor-interacting protein kinases and positively modulate signal transduction pathways converging on activation of the inducible transcription factor NF-kB. [provided by RefSeq, Jul 2008]
Q9BX69 [Direct mapping] Caspase recruitment domain-containing protein 6
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MEMSAT3 predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
