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INPP5K

GENERAL INFORMATION

Gene name

 INPP5K

Gene description

 Inositol polyphosphate-5-phosphatase K

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 9
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Pending external verification. Pending retesting.

Reliability score

 Uncertain based on 1 antibody.
HPA031044
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 INPP5K (HGNC Symbol)

Synonyms

 SKIP

Description

 Inositol polyphosphate-5-phosphatase K (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein with 5-phosphatase activity toward polyphosphate inositol. The protein localizes to the cytosol in regions lacking actin stress fibers. It is thought that this protein may negatively regulate the actin cytoskeleton. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2008]

Chromosome

 17

Cytoband

 p13.3

Chromosome location (bp)

 1494571 - 1516888

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000132376 (version 83.38)

Entrez gene

 51763

UniProt

 Q9BT40 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BT40

Antibodypedia

 INPP5K antibodies

PROTEIN BROWSER
INPP5K-001
INPP5K-003
INPP5K-004
INPP5K-005
INPP5K-006
INPP5K-007
INPP5K-018
INPP5K-021
INPP5K-022

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
INPP5K-001
ENSP00000413937
ENST00000421807
Q9BT40 [Direct mapping]
Inositol polyphosphate 5-phosphatase K
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001701 [in utero embryonic development]
GO:0001726 [ruffle]
GO:0001933 [negative regulation of protein phosphorylation]
GO:0004445 [inositol-polyphosphate 5-phosphatase activity]
GO:0005000 [vasopressin receptor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005802 [trans-Golgi network]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005979 [regulation of glycogen biosynthetic process]
GO:0006469 [negative regulation of protein kinase activity]
GO:0006644 [phospholipid metabolic process]
GO:0006661 [phosphatidylinositol biosynthetic process]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0010801 [negative regulation of peptidyl-threonine phosphorylation]
GO:0010829 [negative regulation of glucose transport]
GO:0016020 [membrane]
GO:0016311 [dephosphorylation]
GO:0016312 [inositol bisphosphate phosphatase activity]
GO:0030036 [actin cytoskeleton organization]
GO:0032587 [ruffle membrane]
GO:0032868 [response to insulin]
GO:0032869 [cellular response to insulin stimulus]
GO:0032870 [cellular response to hormone stimulus]
GO:0033137 [negative regulation of peptidyl-serine phosphorylation]
GO:0034485 [phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity]
GO:0034594 [phosphatidylinositol trisphosphate phosphatase activity]
GO:0034595 [phosphatidylinositol phosphate 5-phosphatase activity]
GO:0035305 [negative regulation of dephosphorylation]
GO:0035810 [positive regulation of urine volume]
GO:0042577 [lipid phosphatase activity]
GO:0042593 [glucose homeostasis]
GO:0043005 [neuron projection]
GO:0043407 [negative regulation of MAP kinase activity]
GO:0043922 [negative regulation by host of viral transcription]
GO:0044281 [small molecule metabolic process]
GO:0045719 [negative regulation of glycogen biosynthetic process]
GO:0045869 [negative regulation of single stranded viral RNA replication via double stranded DNA intermediate]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046030 [inositol trisphosphate phosphatase activity]
GO:0046627 [negative regulation of insulin receptor signaling pathway]
GO:0046855 [inositol phosphate dephosphorylation]
GO:0046856 [phosphatidylinositol dephosphorylation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051497 [negative regulation of stress fiber assembly]
GO:0051898 [negative regulation of protein kinase B signaling]
GO:0051926 [negative regulation of calcium ion transport]
GO:0052658 [inositol-1,4,5-trisphosphate 5-phosphatase activity]
GO:0052659 [inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity]
GO:0071320 [cellular response to cAMP]
GO:0071356 [cellular response to tumor necrosis factor]
GO:0071364 [cellular response to epidermal growth factor stimulus]
GO:0072661 [protein targeting to plasma membrane]
GO:0090315 [negative regulation of protein targeting to membrane]
GO:0097178 [ruffle assembly]
GO:2000466 [negative regulation of glycogen (starch) synthase activity]
GO:2001153 [positive regulation of renal water transport]
Show all
 448 aa
51.1 kDa 		No 0
INPP5K-003
ENSP00000385177
ENST00000406424
Q9BT40 [Direct mapping]
Inositol polyphosphate 5-phosphatase K
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001726 [ruffle]
GO:0001933 [negative regulation of protein phosphorylation]
GO:0004445 [inositol-polyphosphate 5-phosphatase activity]
GO:0005000 [vasopressin receptor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005802 [trans-Golgi network]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005979 [regulation of glycogen biosynthetic process]
GO:0006469 [negative regulation of protein kinase activity]
GO:0006644 [phospholipid metabolic process]
GO:0006661 [phosphatidylinositol biosynthetic process]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0010801 [negative regulation of peptidyl-threonine phosphorylation]
GO:0010829 [negative regulation of glucose transport]
GO:0016020 [membrane]
GO:0016311 [dephosphorylation]
GO:0016312 [inositol bisphosphate phosphatase activity]
GO:0030036 [actin cytoskeleton organization]
GO:0032587 [ruffle membrane]
GO:0032869 [cellular response to insulin stimulus]
GO:0032870 [cellular response to hormone stimulus]
GO:0033137 [negative regulation of peptidyl-serine phosphorylation]
GO:0034485 [phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity]
GO:0034594 [phosphatidylinositol trisphosphate phosphatase activity]
GO:0034595 [phosphatidylinositol phosphate 5-phosphatase activity]
GO:0035305 [negative regulation of dephosphorylation]
GO:0035810 [positive regulation of urine volume]
GO:0042577 [lipid phosphatase activity]
GO:0042593 [glucose homeostasis]
GO:0043005 [neuron projection]
GO:0043407 [negative regulation of MAP kinase activity]
GO:0043922 [negative regulation by host of viral transcription]
GO:0044281 [small molecule metabolic process]
GO:0045719 [negative regulation of glycogen biosynthetic process]
GO:0045869 [negative regulation of single stranded viral RNA replication via double stranded DNA intermediate]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046030 [inositol trisphosphate phosphatase activity]
GO:0046627 [negative regulation of insulin receptor signaling pathway]
GO:0046855 [inositol phosphate dephosphorylation]
GO:0046856 [phosphatidylinositol dephosphorylation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051497 [negative regulation of stress fiber assembly]
GO:0051898 [negative regulation of protein kinase B signaling]
GO:0051926 [negative regulation of calcium ion transport]
GO:0052658 [inositol-1,4,5-trisphosphate 5-phosphatase activity]
GO:0052659 [inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity]
GO:0071320 [cellular response to cAMP]
GO:0071356 [cellular response to tumor necrosis factor]
GO:0071364 [cellular response to epidermal growth factor stimulus]
GO:0072661 [protein targeting to plasma membrane]
GO:0090315 [negative regulation of protein targeting to membrane]
GO:0097178 [ruffle assembly]
GO:2000466 [negative regulation of glycogen (starch) synthase activity]
GO:2001153 [positive regulation of renal water transport]
Show all
 372 aa
42.8 kDa 		No 0
INPP5K-004
ENSP00000318476
ENST00000320345
Q9BT40 [Direct mapping]
Inositol polyphosphate 5-phosphatase K
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001726 [ruffle]
GO:0001933 [negative regulation of protein phosphorylation]
GO:0004445 [inositol-polyphosphate 5-phosphatase activity]
GO:0005000 [vasopressin receptor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005802 [trans-Golgi network]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005979 [regulation of glycogen biosynthetic process]
GO:0006469 [negative regulation of protein kinase activity]
GO:0006644 [phospholipid metabolic process]
GO:0006661 [phosphatidylinositol biosynthetic process]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0010801 [negative regulation of peptidyl-threonine phosphorylation]
GO:0010829 [negative regulation of glucose transport]
GO:0016020 [membrane]
GO:0016311 [dephosphorylation]
GO:0016312 [inositol bisphosphate phosphatase activity]
GO:0030036 [actin cytoskeleton organization]
GO:0032587 [ruffle membrane]
GO:0032869 [cellular response to insulin stimulus]
GO:0032870 [cellular response to hormone stimulus]
GO:0033137 [negative regulation of peptidyl-serine phosphorylation]
GO:0034485 [phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity]
GO:0034594 [phosphatidylinositol trisphosphate phosphatase activity]
GO:0034595 [phosphatidylinositol phosphate 5-phosphatase activity]
GO:0035305 [negative regulation of dephosphorylation]
GO:0035810 [positive regulation of urine volume]
GO:0042577 [lipid phosphatase activity]
GO:0042593 [glucose homeostasis]
GO:0043005 [neuron projection]
GO:0043407 [negative regulation of MAP kinase activity]
GO:0043922 [negative regulation by host of viral transcription]
GO:0044281 [small molecule metabolic process]
GO:0045719 [negative regulation of glycogen biosynthetic process]
GO:0045869 [negative regulation of single stranded viral RNA replication via double stranded DNA intermediate]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046030 [inositol trisphosphate phosphatase activity]
GO:0046627 [negative regulation of insulin receptor signaling pathway]
GO:0046855 [inositol phosphate dephosphorylation]
GO:0046856 [phosphatidylinositol dephosphorylation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051497 [negative regulation of stress fiber assembly]
GO:0051898 [negative regulation of protein kinase B signaling]
GO:0051926 [negative regulation of calcium ion transport]
GO:0052658 [inositol-1,4,5-trisphosphate 5-phosphatase activity]
GO:0052659 [inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity]
GO:0071320 [cellular response to cAMP]
GO:0071356 [cellular response to tumor necrosis factor]
GO:0071364 [cellular response to epidermal growth factor stimulus]
GO:0072661 [protein targeting to plasma membrane]
GO:0090315 [negative regulation of protein targeting to membrane]
GO:0097178 [ruffle assembly]
GO:2000466 [negative regulation of glycogen (starch) synthase activity]
GO:2001153 [positive regulation of renal water transport]
Show all
 372 aa
42.8 kDa 		No 0
INPP5K-005
ENSP00000466929
ENST00000498390
K7ENF7 [Direct mapping]
Inositol polyphosphate 5-phosphatase K
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 23 aa
2.7 kDa 		No 0
INPP5K-006
ENSP00000467376
ENST00000477910
K7EPG6 [Direct mapping]
Inositol polyphosphate 5-phosphatase K
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 50 aa
5.7 kDa 		No 0
INPP5K-007
ENSP00000413259
ENST00000449479
C9JZB0 [Direct mapping]
Inositol polyphosphate 5-phosphatase K
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016787 [hydrolase activity]
GO:0046856 [phosphatidylinositol dephosphorylation]
Show all
 229 aa
26.7 kDa 		No 0
INPP5K-018
ENSP00000458413
ENST00000571274
I3L0Y0 [Direct mapping]
Inositol polyphosphate 5-phosphatase K
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 85 aa
9.7 kDa 		No 0
INPP5K-021
ENSP00000459758
ENST00000575172
I3L2L1 [Direct mapping]
Inositol polyphosphate 5-phosphatase K
Show all
   SPOCTOPUS predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016787 [hydrolase activity]
GO:0046856 [phosphatidylinositol dephosphorylation]
Show all
 158 aa
17.9 kDa 		No 0
INPP5K-022
ENSP00000461105
ENST00000574561
I3L4A5 [Direct mapping]
Inositol polyphosphate 5-phosphatase K
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 154 aa
17.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.