Expression of SERPINF1 in cancer - Summary

CANCER ATLAS

Gene description

Serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1

Protein class

Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA005825

GENE INFORMATION
Gene name	SERPINF1 (HGNC Symbol)
Synonyms	EPC-1, PEDF, PIG35
Description	Serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the serpin family, although it does not display the serine protease inhibitory activity shown by many of the other serpin family members. The encoded protein is secreted and strongly inhibits angiogenesis. In addition, this protein is a neurotrophic factor involved in neuronal differentiation in retinoblastoma cells.[provided by RefSeq, Mar 2011]
Chromosome	17
Cytoband	p13.3
Chromosome location (bp)	1761959 - 1777574
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000132386 (version 83.38)
Entrez gene	5176
UniProt	P36955 (UniProt - Evidence at protein level)
neXtProt	NX_P36955
Antibodypedia	SERPINF1 antibodies

PROTEIN BROWSER

SERPINF1-001	SERPINF1-003	SERPINF1-004	SERPINF1-009	SERPINF1-010	SERPINF1-011	SERPINF1-012	SERPINF1-013

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SERPINF1-001 ENSP00000254722 ENST00000254722	P36955 [Direct mapping] Pigment epithelium-derived factor Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001822 [kidney development] GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005604 [basement membrane] GO:0005615 [extracellular space] GO:0007275 [multicellular organismal development] GO:0007568 [aging] GO:0007614 [short-term memory] GO:0008283 [cell proliferation] GO:0010447 [response to acidic pH] GO:0010596 [negative regulation of endothelial cell migration] GO:0010629 [negative regulation of gene expression] GO:0010951 [negative regulation of endopeptidase activity] GO:0010976 [positive regulation of neuron projection development] GO:0016525 [negative regulation of angiogenesis] GO:0030424 [axon] GO:0031012 [extracellular matrix] GO:0042470 [melanosome] GO:0042698 [ovulation cycle] GO:0043025 [neuronal cell body] GO:0043203 [axon hillock] GO:0046685 [response to arsenic-containing substance] GO:0048471 [perinuclear region of cytoplasm] GO:0050728 [negative regulation of inflammatory response] GO:0050769 [positive regulation of neurogenesis] GO:0060041 [retina development in camera-type eye] GO:0060770 [negative regulation of epithelial cell proliferation involved in prostate gland development] GO:0070062 [extracellular exosome] GO:0071279 [cellular response to cobalt ion] GO:0071300 [cellular response to retinoic acid] GO:0071333 [cellular response to glucose stimulus] GO:0071549 [cellular response to dexamethasone stimulus] GO:1901215 [negative regulation of neuron death] Show all	418 aa 46.3 kDa	Yes	0
SERPINF1-003 ENSP00000459869 ENST00000570731	I3L2R7 [Direct mapping] Pigment epithelium-derived factor Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0010951 [negative regulation of endopeptidase activity] Show all	132 aa 14 kDa	Yes	0
SERPINF1-004 ENSP00000460842 ENST00000577053	I3L3Z3 [Direct mapping] Pigment epithelium-derived factor Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0010951 [negative regulation of endopeptidase activity] Show all	111 aa 11.8 kDa	Yes	0
SERPINF1-009 ENSP00000461214 ENST00000576406	I3L4F9 [Direct mapping] Pigment epithelium-derived factor Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005615 [extracellular space] GO:0010951 [negative regulation of endopeptidase activity] Show all	91 aa 10.3 kDa	No	0
SERPINF1-010 ENSP00000461660 ENST00000571360	I3L4Z0 [Direct mapping] Pigment epithelium-derived factor Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005615 [extracellular space] GO:0010951 [negative regulation of endopeptidase activity] Show all	128 aa 13.8 kDa	Yes	0
SERPINF1-011 ENSP00000460905 ENST00000571149	I3L425 [Direct mapping] Pigment epithelium-derived factor Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0010951 [negative regulation of endopeptidase activity] Show all	87 aa 9.1 kDa	Yes	0
SERPINF1-012 ENSP00000461405 ENST00000573763	I3L4N7 [Direct mapping] Pigment epithelium-derived factor Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0010951 [negative regulation of endopeptidase activity] Show all	138 aa 15.9 kDa	No	0
SERPINF1-013 ENSP00000458484 ENST00000572048	I3L107 [Direct mapping] Pigment epithelium-derived factor Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005615 [extracellular space] GO:0010951 [negative regulation of endopeptidase activity] Show all	99 aa 11.2 kDa	No	0