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UBE2G1

GENERAL INFORMATION

Gene name

 UBE2G1

Gene description

 Ubiquitin-conjugating enzyme E2G 1

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA045681 , HPA050551
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Nasopharynx
N/A
N/A
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 UBE2G1 (HGNC Symbol)

Synonyms

 UBC7, UBE2G

Description

 Ubiquitin-conjugating enzyme E2G 1 (HGNC Symbol)

Entrez gene summary

 The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family and catalyzes the covalent attachment of ubiquitin to other proteins. The protein may be involved in degradation of muscle-specific proteins. [provided by RefSeq, Jul 2008]

Chromosome

 17

Cytoband

 p13.2

Chromosome location (bp)

 4269259 - 4366628

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000132388 (version 83.38)

Entrez gene

 7326

UniProt

 P62253 (UniProt - Evidence at protein level)

neXtProt

 NX_P62253

Antibodypedia

 UBE2G1 antibodies

PROTEIN BROWSER
UBE2G1-001
UBE2G1-002
UBE2G1-003
UBE2G1-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
UBE2G1-001
ENSP00000380178
ENST00000396981
P62253 [Direct mapping]
Ubiquitin-conjugating enzyme E2 G1 Ubiquitin-conjugating enzyme E2 G1, N-terminally processed
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Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0031625 [ubiquitin protein ligase binding]
GO:0044257 [cellular protein catabolic process]
GO:0061630 [ubiquitin protein ligase activity]
GO:0061631 [ubiquitin conjugating enzyme activity]
GO:0070062 [extracellular exosome]
GO:0070534 [protein K63-linked ubiquitination]
GO:0070936 [protein K48-linked ubiquitination]
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 170 aa
19.5 kDa 		No 0
UBE2G1-002
ENSP00000459691
ENST00000572484
I3L2H7 [Direct mapping]
Ubiquitin-conjugating enzyme E2 G1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0061630 [ubiquitin protein ligase activity]
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 99 aa
11.4 kDa 		No 0
UBE2G1-003
ENSP00000459485
ENST00000574059
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 6 aa
0.8 kDa 		No 0
UBE2G1-004
ENSP00000467502
ENST00000571953
K7EPR7 [Direct mapping]
Ubiquitin-conjugating enzyme E2 G1; Ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast), isoform CRA_a
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0061630 [ubiquitin protein ligase activity]
Show all
 78 aa
9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.