Expression of COQ3 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Coenzyme Q3 methyltransferase

Protein class

Enzymes, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA031273	HPA031274

GENE INFORMATION
Gene name	COQ3 (HGNC Symbol)
Synonyms	bA9819.1
Description	Coenzyme Q3 methyltransferase (HGNC Symbol)
Entrez gene summary	Ubiquinone, also known as coenzyme Q, or Q, is a critical component of the electron transport pathways of both eukaryotes and prokaryotes (Jonassen and Clarke, 2000 [PubMed 10777520]). This lipid consists of a hydrophobic isoprenoid tail and a quinone head group. The tail varies in length depending on the organism, but its purpose is to anchor coenzyme Q to the membrane. The quinone head group is responsible for the activity of coenzyme Q in the respiratory chain. The S. cerevisiae COQ3 gene encodes an O-methyltransferase required for 2 steps in the biosynthetic pathway of coenzyme Q. This enzyme methylates an early coenzyme Q intermediate, 3,4-dihydroxy-5-polyprenylbenzoic acid, as well as the final intermediate in the pathway, converting demethyl-ubiquinone to coenzyme Q. The COQ3 gene product is also capable of methylating the distinct prokaryotic early intermediate 2-hydroxy-6-polyprenyl phenol.[supplied by OMIM, Mar 2008]
Chromosome	6
Cytoband	q16.2
Chromosome location (bp)	99369400 - 99394204
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000132423 (version 83.38)
Entrez gene	51805
UniProt	Q9NZJ6 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NZJ6
Antibodypedia	COQ3 antibodies

PROTEIN BROWSER

COQ3-001	COQ3-002	COQ3-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
COQ3-001 ENSP00000254759 ENST00000254759	Q9NZJ6 [Direct mapping] Ubiquinone biosynthesis O-methyltransferase, mitochondrial Show all	Enzymes ENZYME proteins Transferases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004395 [hexaprenyldihydroxybenzoate methyltransferase activity] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005759 [mitochondrial matrix] GO:0006071 [glycerol metabolic process] GO:0006744 [ubiquinone biosynthetic process] GO:0008171 [O-methyltransferase activity] GO:0008425 [2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity] GO:0008689 [3-demethylubiquinone-9 3-O-methyltransferase activity] GO:0032259 [methylation] GO:0044281 [small molecule metabolic process] Show all	369 aa 41.1 kDa	No	0
COQ3-002 ENSP00000358243 ENST00000369240	F6WGP0 [Direct mapping] Ubiquinone biosynthesis O-methyltransferase, mitochondrial Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006744 [ubiquinone biosynthetic process] GO:0008425 [2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity] GO:0032259 [methylation] Show all	141 aa 15.4 kDa	No	0
COQ3-201 ENSP00000358245 ENST00000369242	Q5T063 [Direct mapping] Ubiquinone biosynthesis O-methyltransferase, mitochondrial Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006744 [ubiquinone biosynthetic process] GO:0008425 [2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity] GO:0032259 [methylation] Show all	310 aa 34.6 kDa	No	0