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POLR3F

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GENERAL INFORMATION

Gene name

 POLR3F

Gene description

 Polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa

Protein class

 Predicted intracellular proteins
RNA polymerase related proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nucleus.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleus (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA072298
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nucleus.

Main location

 Nucleus (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA072298 RH-30 Nucleoplasm
HPA072298 SK-MEL-30 Nucleoplasm
HPA072298 U-2 OS Nucleus

GENE INFORMATION

Gene name

 POLR3F (HGNC Symbol)

Synonyms

 RPC39, RPC6

Description

 Polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is one of more than a dozen subunits forming eukaryotic RNA polymerase III (RNA Pol III), which transcribes 5S ribosomal RNA and tRNA genes. This protein has been shown to bind both TFIIIB90 and TBP, two subunits of RNA polymerase III transcription initiation factor IIIB (TFIIIB). Unlike most of the other RNA Pol III subunits, the encoded protein is unique to this polymerase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

Chromosome

 20

Cytoband

 p11.23

Chromosome location (bp)

 18467127 - 18484643

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000132664 (version 83.38)

Entrez gene

 10621

UniProt

 Q9H1D9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9H1D9

Antibodypedia

 POLR3F antibodies

PROTEIN BROWSER
POLR3F-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
POLR3F-001
ENSP00000366828
ENST00000377603
Q9H1D9 [Direct mapping]
DNA-directed RNA polymerase III subunit RPC6
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Predicted intracellular proteins
RNA polymerase related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001056 [RNA polymerase III activity]
GO:0003677 [DNA binding]
GO:0003899 [DNA-directed RNA polymerase activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005666 [DNA-directed RNA polymerase III complex]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006359 [regulation of transcription from RNA polymerase III promoter]
GO:0006383 [transcription from RNA polymerase III promoter]
GO:0006385 [transcription elongation from RNA polymerase III promoter]
GO:0006386 [termination of RNA polymerase III transcription]
GO:0010467 [gene expression]
GO:0032481 [positive regulation of type I interferon production]
GO:0032728 [positive regulation of interferon-beta production]
GO:0045087 [innate immune response]
GO:0045089 [positive regulation of innate immune response]
GO:0051607 [defense response to virus]
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 316 aa
35.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.