Expression of SSTR4 in cancer - Summary

CANCER ATLAS

Gene description

Somatostatin receptor 4

Protein class

G-protein coupled receptors, Predicted membrane proteins

Protein evidence

Evidence at transcript level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Pancreatic cancer

STAINING SUMMARY

HPA064252

GENE INFORMATION
Gene name	SSTR4
Synonyms
Description	Somatostatin receptor 4 (HGNC Symbol)
Entrez gene summary	Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR4 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in fetal and adult brain and lung. [provided by RefSeq, Jul 2008]
Chromosome	20
Cytoband	p11.21
Chromosome location (bp)	23035386 - 23036812
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000132671 (version 83.38)
Entrez gene	6754
UniProt	P31391 (UniProt - Evidence at transcript level)
neXtProt	NX_P31391
Antibodypedia	SSTR4 antibodies

PROTEIN BROWSER

SSTR4-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SSTR4-001 ENSP00000255008 ENST00000255008	P31391 [Direct mapping] Somatostatin receptor type 4 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0004994 [somatostatin receptor activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger] GO:0007218 [neuropeptide signaling pathway] GO:0007268 [synaptic transmission] GO:0008285 [negative regulation of cell proliferation] GO:0016021 [integral component of membrane] GO:0016477 [cell migration] GO:0019369 [arachidonic acid metabolic process] GO:0030815 [negative regulation of cAMP metabolic process] GO:0030900 [forebrain development] GO:0038170 [somatostatin signaling pathway] GO:0042923 [neuropeptide binding] GO:0043005 [neuron projection] GO:0043410 [positive regulation of MAPK cascade] GO:0071385 [cellular response to glucocorticoid stimulus] Show all	388 aa 42 kDa	No	7