Tissue expression of ATP1A4 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	ATP1A4
Gene description	ATPase, Na+/K+ transporting, alpha 4 polypeptide
Protein class	Enzymes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (testis, placenta, urinary bladder)
GTEx:	Tissue enriched (testis)
FANTOM5:	Tissue enhanced (testis, seminal vesicle)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (testis, placenta, urinary bladder)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (testis)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (testis, seminal vesicle)

GENE INFORMATION
Gene name	ATP1A4 (HGNC Symbol)
Synonyms	ATP1AL2
Description	ATPase, Na+/K+ transporting, alpha 4 polypeptide (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 4 subunit. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	q23.2
Chromosome location (bp)	160151570 - 160186977
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000132681 (version 83.38)
Entrez gene	480
UniProt	Q13733 (UniProt - Evidence at protein level)
neXtProt	NX_Q13733
Antibodypedia	ATP1A4 antibodies

PROTEIN BROWSER

ATP1A4-001	ATP1A4-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ATP1A4-001 ENSP00000357060 ENST00000368081	Q13733 [Direct mapping] Sodium/potassium-transporting ATPase subunit alpha-4 Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0005391 [sodium:potassium-exchanging ATPase activity] GO:0005524 [ATP binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005890 [sodium:potassium-exchanging ATPase complex] GO:0006813 [potassium ion transport] GO:0006814 [sodium ion transport] GO:0006883 [cellular sodium ion homeostasis] GO:0007283 [spermatogenesis] GO:0008152 [metabolic process] GO:0009566 [fertilization] GO:0010107 [potassium ion import] GO:0015991 [ATP hydrolysis coupled proton transport] GO:0016021 [integral component of membrane] GO:0030007 [cellular potassium ion homeostasis] GO:0030317 [sperm motility] GO:0030641 [regulation of cellular pH] GO:0034220 [ion transmembrane transport] GO:0036376 [sodium ion export from cell] GO:0042391 [regulation of membrane potential] GO:0043231 [intracellular membrane-bounded organelle] GO:0046872 [metal ion binding] GO:0055085 [transmembrane transport] Show all	1029 aa 114.2 kDa	No	>9
ATP1A4-006 ENSP00000433094 ENST00000470705	Q13733 [Direct mapping] Sodium/potassium-transporting ATPase subunit alpha-4 Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Show all	GO:0005391 [sodium:potassium-exchanging ATPase activity] GO:0005524 [ATP binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005890 [sodium:potassium-exchanging ATPase complex] GO:0006813 [potassium ion transport] GO:0006814 [sodium ion transport] GO:0006883 [cellular sodium ion homeostasis] GO:0008152 [metabolic process] GO:0010107 [potassium ion import] GO:0015991 [ATP hydrolysis coupled proton transport] GO:0030007 [cellular potassium ion homeostasis] GO:0030317 [sperm motility] GO:0030641 [regulation of cellular pH] GO:0034220 [ion transmembrane transport] GO:0036376 [sodium ion export from cell] GO:0043231 [intracellular membrane-bounded organelle] GO:0046872 [metal ion binding] GO:0055085 [transmembrane transport] Show all	165 aa 19.6 kDa	No	3