Expression of CRP in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

C-reactive protein, pentraxin-related

Protein class

Cancer-related genes, Candidate cardiovascular disease genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA027367	HPA027396	CAB005036

GENE INFORMATION
Gene name	CRP (HGNC Symbol)
Synonyms	PTX1
Description	C-reactive protein, pentraxin-related (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the pentaxin family. It is involved in several host defense related functions based on its ability to recognize foreign pathogens and damaged cells of the host and to initiate their elimination by interacting with humoral and cellular effector systems in the blood. Consequently, the level of this protein in plasma increases greatly during acute phase response to tissue injury, infection, or other inflammatory stimuli. [provided by RefSeq, Sep 2009]
Chromosome	1
Cytoband	q23.2
Chromosome location (bp)	159712289 - 159714589
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000132693 (version 83.38)
Entrez gene	1401
UniProt	P02741 (UniProt - Evidence at protein level)
neXtProt	NX_P02741
Antibodypedia	CRP antibodies

PROTEIN BROWSER

CRP-001	CRP-002	CRP-003	CRP-004	CRP-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CRP-001 ENSP00000255030 ENST00000255030	P02741 [Direct mapping] C-reactive protein C-reactive protein(1-205) Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001849 [complement component C1q binding] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0006953 [acute-phase response] GO:0006954 [inflammatory response] GO:0008228 [opsonization] GO:0010628 [positive regulation of gene expression] GO:0010745 [negative regulation of macrophage derived foam cell differentiation] GO:0010888 [negative regulation of lipid storage] GO:0030169 [low-density lipoprotein particle binding] GO:0032930 [positive regulation of superoxide anion generation] GO:0033265 [choline binding] GO:0045908 [negative regulation of vasodilation] GO:0050750 [low-density lipoprotein particle receptor binding] GO:0050830 [defense response to Gram-positive bacterium] GO:0070062 [extracellular exosome] GO:2000482 [regulation of interleukin-8 secretion] Show all	224 aa 25 kDa	Yes	0
CRP-002 ENSP00000357093 ENST00000368112	P02741 [Direct mapping] C-reactive protein C-reactive protein(1-205) Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0001849 [complement component C1q binding] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0006953 [acute-phase response] GO:0006954 [inflammatory response] GO:0008228 [opsonization] GO:0010628 [positive regulation of gene expression] GO:0010745 [negative regulation of macrophage derived foam cell differentiation] GO:0010888 [negative regulation of lipid storage] GO:0030169 [low-density lipoprotein particle binding] GO:0032930 [positive regulation of superoxide anion generation] GO:0033265 [choline binding] GO:0045908 [negative regulation of vasodilation] GO:0050750 [low-density lipoprotein particle receptor binding] GO:0050830 [defense response to Gram-positive bacterium] GO:0070062 [extracellular exosome] GO:2000482 [regulation of interleukin-8 secretion] Show all	91 aa 10.4 kDa	Yes	0
CRP-003 ENSP00000357091 ENST00000368110	Q5VVP7 [Direct mapping] C-reactive protein Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		102 aa 11.6 kDa	Yes	0
CRP-004 ENSP00000357092 ENST00000368111	Q5VVP7 [Direct mapping] C-reactive protein Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		102 aa 11.6 kDa	Yes	0
CRP-201 ENSP00000402788 ENST00000437342	C9JRE9 [Direct mapping] C-reactive protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		46 aa 5.4 kDa	No	0