Tissue expression of ALDH3B2 - Summary - The Human Protein Atlas

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ALDH3B2

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	ALDH3B2
Gene description	Aldehyde dehydrogenase 3 family, member B2
Protein class	Enzymes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Group enriched (skin, esophagus, breast)
GTEx:	Tissue enhanced (esophagus, skin)
FANTOM5:	Tissue enhanced (tonsil, esophagus, salivary gland)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in several tissues including breast.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA045132
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Group enriched (skin, esophagus, breast)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (esophagus, skin)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (tonsil, esophagus, salivary gland)

GENE INFORMATION
Gene name	ALDH3B2 (HGNC Symbol)
Synonyms	ALDH8
Description	Aldehyde dehydrogenase 3 family, member B2 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the aldehyde dehydrogenase family, a group of isozymes that may play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. The gene of this particular family member is over 10 kb in length. The expression of these transcripts is restricted to the salivary gland among the human tissues examined. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]
Chromosome	11
Cytoband	q13.2
Chromosome location (bp)	67662162 - 67681200
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000132746 (version 83.38)
Entrez gene	222
UniProt	P48448 (UniProt - Evidence at transcript level)
neXtProt	NX_P48448
Antibodypedia	ALDH3B2 antibodies

PROTEIN BROWSER

ALDH3B2-001	ALDH3B2-004	ALDH3B2-007	ALDH3B2-008	ALDH3B2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ALDH3B2-001 ENSP00000431595 ENST00000530069	P48448 [Direct mapping] Aldehyde dehydrogenase family 3 member B2 Show all	Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004028 [3-chloroallyl aldehyde dehydrogenase activity] GO:0004029 [aldehyde dehydrogenase (NAD) activity] GO:0004030 [aldehyde dehydrogenase [NAD(P)+] activity] GO:0006066 [alcohol metabolic process] GO:0006068 [ethanol catabolic process] GO:0006629 [lipid metabolic process] GO:0008152 [metabolic process] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	385 aa 42.6 kDa	No	2
ALDH3B2-004 ENSP00000433718 ENST00000525827	E9PJV0 [Direct mapping] Aldehyde dehydrogenase family 3 member B2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004029 [aldehyde dehydrogenase (NAD) activity] GO:0008152 [metabolic process] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	148 aa 16.1 kDa	No	2
ALDH3B2-007 ENSP00000433466 ENST00000528756	E9PKY9 [Direct mapping] Aldehyde dehydrogenase family 3 member B2 Show all	Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004029 [aldehyde dehydrogenase (NAD) activity] GO:0008152 [metabolic process] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	95 aa 10.4 kDa	No	0
ALDH3B2-008 ENSP00000435476 ENST00000531248	H0YEC0 [Direct mapping] Aldehyde dehydrogenase family 3 member B2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004029 [aldehyde dehydrogenase (NAD) activity] GO:0008152 [metabolic process] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	128 aa 14 kDa	No	0
ALDH3B2-201 ENSP00000255084 ENST00000349015	P48448 [Direct mapping] Aldehyde dehydrogenase family 3 member B2 Show all	Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004028 [3-chloroallyl aldehyde dehydrogenase activity] GO:0004029 [aldehyde dehydrogenase (NAD) activity] GO:0004030 [aldehyde dehydrogenase [NAD(P)+] activity] GO:0006066 [alcohol metabolic process] GO:0006068 [ethanol catabolic process] GO:0006629 [lipid metabolic process] GO:0008152 [metabolic process] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	385 aa 42.6 kDa	No	2

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.