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Strong cytoplasmic staining was observed in several cases of renal and some cases of liver cancer. Few cases of testis cancers and rare case of carcinoid showed weak to moderate cytoplasmic staining. Remaining tumour tissues along with stromal cells in most cases were negative.
Most renal cancers showed moderate cytoplasmic immunoreactivity. Few hepatocellular carcinomas were weak to moderately stained. Remaining cancer tissues were negative.
GENE INFORMATION
Gene name
DMGDH
Synonyms
Description
Dimethylglycine dehydrogenase (HGNC Symbol)
Entrez gene summary
This gene encodes an enzyme involved in the catabolism of choline, catalyzing the oxidative demethylation of dimethylglycine to form sarcosine. The enzyme is found as a monomer in the mitochondrial matrix, and uses flavin adenine dinucleotide and folate as cofactors. Mutation in this gene causes dimethylglycine dehydrogenase deficiency, characterized by a fishlike body odor, chronic muscle fatigue, and elevated levels of the muscle form of creatine kinase in serum. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Enzymes ENZYME proteins Oxidoreductases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
