Tissue expression of SLC14A2 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	SLC14A2
Gene description	Solute carrier family 14 (urea transporter), member 2
Protein class	Plasma proteins Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (kidney)
GTEx:	Tissue enhanced (adrenal gland, kidney)
FANTOM5:	Group enriched (appendix, colon, small intestine)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (kidney)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (adrenal gland, kidney)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Group enriched (appendix, colon, small intestine)

GENE INFORMATION
Gene name	SLC14A2 (HGNC Symbol)
Synonyms	HUT2, UT2
Description	Solute carrier family 14 (urea transporter), member 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the urea transporter family. In mammalian cells, urea is the chief end product of nitrogen catabolism, and plays an important role in the urinary concentration mechanism. This protein is expressed in the inner medulla of the kidney, and mediates rapid transepithelial urea transport across the inner medullary collecting duct. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2011]
Chromosome	18
Cytoband	q12.3
Chromosome location (bp)	45212995 - 45683686
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000132874 (version 83.38)
Entrez gene	8170
UniProt	Q15849 (UniProt - Evidence at protein level)
neXtProt	NX_Q15849
Antibodypedia	SLC14A2 antibodies

PROTEIN BROWSER

SLC14A2-001	SLC14A2-003	SLC14A2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC14A2-001 ENSP00000255226 ENST00000255226	Q15849 [Direct mapping] Urea transporter 2 Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0009414 [response to water deprivation] GO:0015204 [urea transmembrane transporter activity] GO:0015265 [urea channel activity] GO:0015840 [urea transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016324 [apical plasma membrane] GO:0050839 [cell adhesion molecule binding] GO:0055085 [transmembrane transport] GO:0071918 [urea transmembrane transport] Show all	920 aa 101.2 kDa	No	>9
SLC14A2-003 ENSP00000465953 ENST00000586448	Q15849 [Direct mapping] Urea transporter 2 Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0015204 [urea transmembrane transporter activity] GO:0015265 [urea channel activity] GO:0015840 [urea transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016324 [apical plasma membrane] GO:0050839 [cell adhesion molecule binding] GO:0055085 [transmembrane transport] GO:0071918 [urea transmembrane transport] Show all	920 aa 101.2 kDa	No	>9
SLC14A2-201 ENSP00000465349 ENST00000589658	Q15849 [Direct mapping] Urea transporter 2 Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0015204 [urea transmembrane transporter activity] GO:0015265 [urea channel activity] GO:0015840 [urea transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016324 [apical plasma membrane] GO:0050839 [cell adhesion molecule binding] GO:0055085 [transmembrane transport] GO:0071918 [urea transmembrane transport] Show all	920 aa 101.2 kDa	No	>9