Expression of ALOX5AP in cancer - Summary

CANCER ATLAS

Gene description

Arachidonate 5-lipoxygenase-activating protein

Protein class

Disease related genes, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Lymphoma

STAINING SUMMARY

HPA026592

GENE INFORMATION
Gene name	ALOX5AP (HGNC Symbol)
Synonyms	FLAP
Description	Arachidonate 5-lipoxygenase-activating protein (HGNC Symbol)
Entrez gene summary	This gene encodes a protein which, with 5-lipoxygenase, is required for leukotriene synthesis. Leukotrienes are arachidonic acid metabolites which have been implicated in various types of inflammatory responses, including asthma, arthritis and psoriasis. This protein localizes to the plasma membrane. Inhibitors of its function impede translocation of 5-lipoxygenase from the cytoplasm to the cell membrane and inhibit 5-lipoxygenase activation. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2011]
Chromosome	13
Cytoband	q12.3
Chromosome location (bp)	30713478 - 30764426
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000132965 (version 83.38)
Entrez gene	241
UniProt	P20292 (UniProt - Evidence at protein level)
neXtProt	NX_P20292
Antibodypedia	ALOX5AP antibodies

PROTEIN BROWSER

ALOX5AP-001	ALOX5AP-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ALOX5AP-001 ENSP00000369858 ENST00000380490	P20292 [Direct mapping] Arachidonate 5-lipoxygenase-activating protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005635 [nuclear envelope] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006691 [leukotriene metabolic process] GO:0008047 [enzyme activator activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019369 [arachidonic acid metabolic process] GO:0019370 [leukotriene biosynthetic process] GO:0019372 [lipoxygenase pathway] GO:0031965 [nuclear membrane] GO:0043085 [positive regulation of catalytic activity] GO:0044281 [small molecule metabolic process] GO:0047485 [protein N-terminus binding] GO:0050544 [arachidonic acid binding] GO:0070207 [protein homotrimerization] GO:0071277 [cellular response to calcium ion] GO:2001300 [lipoxin metabolic process] Show all	161 aa 18.2 kDa	No	3
ALOX5AP-201 ENSP00000479870 ENST00000617770	A0A087WW23 [Direct mapping] Arachidonate 5-lipoxygenase-activating protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002540 [leukotriene production involved in inflammatory response] GO:0002675 [positive regulation of acute inflammatory response] GO:0004051 [arachidonate 5-lipoxygenase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005783 [endoplasmic reticulum] GO:0005829 [cytosol] GO:0006691 [leukotriene metabolic process] GO:0008047 [enzyme activator activity] GO:0016021 [integral component of membrane] GO:0019370 [leukotriene biosynthetic process] GO:0019899 [enzyme binding] GO:0042803 [protein homodimerization activity] GO:0043085 [positive regulation of catalytic activity] GO:0046982 [protein heterodimerization activity] GO:0055114 [oxidation-reduction process] GO:0070207 [protein homotrimerization] Show all	218 aa 24.2 kDa	No	3