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MYH8

GENERAL INFORMATION

Gene name

 MYH8

Gene description

 Myosin, heavy chain 8, skeletal muscle, perinatal

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (esophagus, skeletal muscle)
GTEx:Tissue enriched (skeletal muscle)
FANTOM5:Tissue enhanced (skeletal muscle)

Protein evidence

 Evidence at protein level

Protein expression

 Selective cytoplasmic expression in heart and skeletal muscle.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Supported based on 2 antibodies.
HPA001349 , CAB016527
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Skeletal muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (esophagus, skeletal muscle)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (skeletal muscle)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (skeletal muscle)

GENE INFORMATION

Gene name

 MYH8 (HGNC Symbol)

Synonyms

 MyHC-peri, MyHC-pn

Description

 Myosin, heavy chain 8, skeletal muscle, perinatal (HGNC Symbol)

Entrez gene summary

 Myosins are actin-based motor proteins that function in the generation of mechanical force in eukaryotic cells. Muscle myosins are heterohexamers composed of 2 myosin heavy chains and 2 pairs of nonidentical myosin light chains. This gene encodes a member of the class II or conventional myosin heavy chains, and functions in skeletal muscle contraction. This gene is predominantly expressed in fetal skeletal muscle. This gene is found in a cluster of myosin heavy chain genes on chromosome 17. A mutation in this gene results in trismus-pseudocamptodactyly syndrome. [provided by RefSeq, Sep 2009]

Chromosome

 17

Cytoband

 p13.1

Chromosome location (bp)

 10390322 - 10421950

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000133020 (version 83.38)

Entrez gene

 4626

UniProt

 P13535 (UniProt - Evidence at protein level)

neXtProt

 NX_P13535

Antibodypedia

 MYH8 antibodies

PROTEIN BROWSER
MYH8-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MYH8-001
ENSP00000384330
ENST00000403437
P13535 [Direct mapping]
Myosin-8
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Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000146 [microfilament motor activity]
GO:0003009 [skeletal muscle contraction]
GO:0003774 [motor activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005859 [muscle myosin complex]
GO:0006936 [muscle contraction]
GO:0008307 [structural constituent of muscle]
GO:0016459 [myosin complex]
GO:0016887 [ATPase activity]
GO:0030017 [sarcomere]
GO:0030049 [muscle filament sliding]
GO:0032027 [myosin light chain binding]
GO:0032982 [myosin filament]
GO:0046034 [ATP metabolic process]
GO:0051015 [actin filament binding]
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 1937 aa
222.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.