Expression of LGR6 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Leucine-rich repeat containing G protein-coupled receptor 6

Protein class

G-protein coupled receptors, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA008556

GENE INFORMATION
Gene name	LGR6 (HGNC Symbol)
Synonyms	FLJ14471
Description	Leucine-rich repeat containing G protein-coupled receptor 6 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the leucine-rich repeat-containing subgroup of the G protein-coupled 7-transmembrane protein superfamily. The encoded protein is a glycoprotein hormone receptor with a large N-terminal extracellular domain that contains leucine-rich repeats important for the formation of a horseshoe-shaped interaction motif for ligand binding. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	q32.1
Chromosome location (bp)	202193901 - 202319781
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000133067 (version 83.38)
Entrez gene	59352
UniProt	Q9HBX8 (UniProt - Evidence at protein level)
neXtProt	NX_Q9HBX8
Antibodypedia	LGR6 antibodies

PROTEIN BROWSER

LGR6-001	LGR6-002	LGR6-003	LGR6-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LGR6-001 ENSP00000356247 ENST00000367278	Q9HBX8 [Direct mapping] Leucine-rich repeat-containing G-protein coupled receptor 6 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Plasma proteins Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0016055 [Wnt signaling pathway] GO:0030177 [positive regulation of Wnt signaling pathway] GO:0030335 [positive regulation of cell migration] GO:0031982 [vesicle] GO:0032588 [trans-Golgi network membrane] GO:0090263 [positive regulation of canonical Wnt signaling pathway] Show all	967 aa 104.3 kDa	Yes	7
LGR6-002 ENSP00000255432 ENST00000255432	Q9HBX8 [Direct mapping] Leucine-rich repeat-containing G-protein coupled receptor 6 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Plasma proteins Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0016055 [Wnt signaling pathway] GO:0030177 [positive regulation of Wnt signaling pathway] GO:0030335 [positive regulation of cell migration] GO:0031982 [vesicle] GO:0032588 [trans-Golgi network membrane] GO:0090263 [positive regulation of canonical Wnt signaling pathway] Show all	915 aa 99.3 kDa	No	7
LGR6-003 ENSP00000387869 ENST00000439764	Q9HBX8 [Direct mapping] Leucine-rich repeat-containing G-protein coupled receptor 6 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Plasma proteins Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0016055 [Wnt signaling pathway] GO:0030177 [positive regulation of Wnt signaling pathway] GO:0030335 [positive regulation of cell migration] GO:0031982 [vesicle] GO:0032588 [trans-Golgi network membrane] GO:0090263 [positive regulation of canonical Wnt signaling pathway] Show all	828 aa 89.3 kDa	No	7
LGR6-006 ENSP00000402284 ENST00000423542	Q5T508 [Direct mapping] Leucine-rich repeat-containing G-protein-coupled receptor 6 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] Show all	232 aa 26.2 kDa	No	0