Tissue expression of TRPC4 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	TRPC4
Gene description	Transient receptor potential cation channel, subfamily C, member 4
Protein class	Plasma proteins Predicted membrane proteins Voltage-gated ion channels
Predicted localization	Membrane
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (endometrium, smooth muscle, seminal vesicle)
GTEx:	Tissue enhanced (endometrium)
FANTOM5:	Tissue enhanced (endometrium)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (endometrium, smooth muscle, seminal vesicle)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (endometrium)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (endometrium)

GENE INFORMATION
Gene name	TRPC4 (HGNC Symbol)
Synonyms	HTRP4, TRP4
Description	Transient receptor potential cation channel, subfamily C, member 4 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the canonical subfamily of transient receptor potential cation channels. The encoded protein forms a non-selective calcium-permeable cation channel that is activated by Gq-coupled receptors and tyrosine kinases, and plays a role in multiple processes including endothelial permeability, vasodilation, neurotransmitter release and cell proliferation. Single nucleotide polymorphisms in this gene may be associated with generalized epilepsy with photosensitivity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]
Chromosome	13
Cytoband	q13.3
Chromosome location (bp)	37636636 - 37870425
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000133107 (version 83.38)
Entrez gene	7223
UniProt	Q9UBN4 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UBN4
Antibodypedia	TRPC4 antibodies

PROTEIN BROWSER

TRPC4-001	TRPC4-002	TRPC4-003	TRPC4-004	TRPC4-006	TRPC4-008	TRPC4-201	TRPC4-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TRPC4-001 ENSP00000369027 ENST00000379705	Q9UBN4 [Direct mapping] Short transient receptor potential channel 4 Show all	Voltage-gated ion channels Transient Receptor Potential Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Plasma proteins Show all	GO:0005216 [ion channel activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005911 [cell-cell junction] GO:0006811 [ion transport] GO:0006816 [calcium ion transport] GO:0006828 [manganese ion transport] GO:0007411 [axon guidance] GO:0008013 [beta-catenin binding] GO:0009986 [cell surface] GO:0015279 [store-operated calcium channel activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0030863 [cortical cytoskeleton] GO:0034220 [ion transmembrane transport] GO:0034704 [calcium channel complex] GO:0045296 [cadherin binding] GO:0051480 [cytosolic calcium ion homeostasis] GO:0055085 [transmembrane transport] GO:0070509 [calcium ion import] GO:0070588 [calcium ion transmembrane transport] GO:0070679 [inositol 1,4,5 trisphosphate binding] Show all	977 aa 112.1 kDa	No	8
TRPC4-002 ENSP00000348025 ENST00000355779	Q9UBN4 [Direct mapping] Short transient receptor potential channel 4 Show all	Voltage-gated ion channels Transient Receptor Potential Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Plasma proteins Show all	GO:0005216 [ion channel activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005911 [cell-cell junction] GO:0006811 [ion transport] GO:0006816 [calcium ion transport] GO:0006828 [manganese ion transport] GO:0007411 [axon guidance] GO:0008013 [beta-catenin binding] GO:0009986 [cell surface] GO:0015279 [store-operated calcium channel activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0030863 [cortical cytoskeleton] GO:0034220 [ion transmembrane transport] GO:0034704 [calcium channel complex] GO:0045296 [cadherin binding] GO:0051480 [cytosolic calcium ion homeostasis] GO:0055085 [transmembrane transport] GO:0070509 [calcium ion import] GO:0070588 [calcium ion transmembrane transport] GO:0070679 [inositol 1,4,5 trisphosphate binding] Show all	836 aa 96.4 kDa	No	8
TRPC4-003 ENSP00000351264 ENST00000358477	Q9UBN4 [Direct mapping] Short transient receptor potential channel 4 Show all	Voltage-gated ion channels Transient Receptor Potential Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Plasma proteins Show all	GO:0005216 [ion channel activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005911 [cell-cell junction] GO:0006811 [ion transport] GO:0006816 [calcium ion transport] GO:0006828 [manganese ion transport] GO:0007411 [axon guidance] GO:0008013 [beta-catenin binding] GO:0009986 [cell surface] GO:0015279 [store-operated calcium channel activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0030863 [cortical cytoskeleton] GO:0034220 [ion transmembrane transport] GO:0034704 [calcium channel complex] GO:0045296 [cadherin binding] GO:0051480 [cytosolic calcium ion homeostasis] GO:0055085 [transmembrane transport] GO:0070509 [calcium ion import] GO:0070588 [calcium ion transmembrane transport] GO:0070679 [inositol 1,4,5 trisphosphate binding] Show all	893 aa 102.6 kDa	No	8
TRPC4-004 ENSP00000368995 ENST00000379673	Q9UBN4 [Direct mapping] Short transient receptor potential channel 4 Show all	Voltage-gated ion channels Transient Receptor Potential Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Plasma proteins Show all	GO:0005216 [ion channel activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005911 [cell-cell junction] GO:0006811 [ion transport] GO:0006816 [calcium ion transport] GO:0006828 [manganese ion transport] GO:0007411 [axon guidance] GO:0008013 [beta-catenin binding] GO:0009986 [cell surface] GO:0015279 [store-operated calcium channel activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0030863 [cortical cytoskeleton] GO:0034220 [ion transmembrane transport] GO:0034704 [calcium channel complex] GO:0045296 [cadherin binding] GO:0051480 [cytosolic calcium ion homeostasis] GO:0055085 [transmembrane transport] GO:0070509 [calcium ion import] GO:0070588 [calcium ion transmembrane transport] GO:0070679 [inositol 1,4,5 trisphosphate binding] Show all	828 aa 94.9 kDa	No	8
TRPC4-006 ENSP00000369001 ENST00000379679	Q9UBN4 [Direct mapping] Short transient receptor potential channel 4 Show all	Voltage-gated ion channels Transient Receptor Potential Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Plasma proteins Show all	GO:0005216 [ion channel activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005911 [cell-cell junction] GO:0006811 [ion transport] GO:0006816 [calcium ion transport] GO:0006828 [manganese ion transport] GO:0007411 [axon guidance] GO:0008013 [beta-catenin binding] GO:0009986 [cell surface] GO:0015279 [store-operated calcium channel activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0030863 [cortical cytoskeleton] GO:0034220 [ion transmembrane transport] GO:0034704 [calcium channel complex] GO:0045296 [cadherin binding] GO:0051480 [cytosolic calcium ion homeostasis] GO:0055085 [transmembrane transport] GO:0070509 [calcium ion import] GO:0070588 [calcium ion transmembrane transport] GO:0070679 [inositol 1,4,5 trisphosphate binding] Show all	804 aa 92.2 kDa	No	8
TRPC4-008 ENSP00000486109 ENST00000625583	Q9UBN4 [Direct mapping] Short transient receptor potential channel 4 Show all	Voltage-gated ion channels Transient Receptor Potential Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Plasma proteins Show all	GO:0005216 [ion channel activity] GO:0005262 [calcium channel activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005901 [caveola] GO:0005911 [cell-cell junction] GO:0006811 [ion transport] GO:0006816 [calcium ion transport] GO:0006828 [manganese ion transport] GO:0007411 [axon guidance] GO:0008013 [beta-catenin binding] GO:0009986 [cell surface] GO:0014051 [gamma-aminobutyric acid secretion] GO:0015279 [store-operated calcium channel activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0030863 [cortical cytoskeleton] GO:0034220 [ion transmembrane transport] GO:0034704 [calcium channel complex] GO:0043234 [protein complex] GO:0045121 [membrane raft] GO:0045296 [cadherin binding] GO:0048709 [oligodendrocyte differentiation] GO:0051480 [cytosolic calcium ion homeostasis] GO:0051924 [regulation of calcium ion transport] GO:0055085 [transmembrane transport] GO:0070509 [calcium ion import] GO:0070588 [calcium ion transmembrane transport] GO:0070679 [inositol 1,4,5 trisphosphate binding] Show all	982 aa 112.7 kDa	No	8
TRPC4-201 ENSP00000342580 ENST00000338947	Q9UBN4 [Direct mapping] Short transient receptor potential channel 4 Show all	Voltage-gated ion channels Transient Receptor Potential Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Plasma proteins Show all	GO:0005216 [ion channel activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005911 [cell-cell junction] GO:0006811 [ion transport] GO:0006816 [calcium ion transport] GO:0006828 [manganese ion transport] GO:0007411 [axon guidance] GO:0008013 [beta-catenin binding] GO:0009986 [cell surface] GO:0015279 [store-operated calcium channel activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0030863 [cortical cytoskeleton] GO:0034220 [ion transmembrane transport] GO:0034704 [calcium channel complex] GO:0045296 [cadherin binding] GO:0051480 [cytosolic calcium ion homeostasis] GO:0055085 [transmembrane transport] GO:0070509 [calcium ion import] GO:0070588 [calcium ion transmembrane transport] GO:0070679 [inositol 1,4,5 trisphosphate binding] Show all	804 aa 92.2 kDa	No	8
TRPC4-202 ENSP00000410133 ENST00000426868	Q3MHB9 [Direct mapping] Short transient receptor potential channel 4; TRPC4 protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0005262 [calcium channel activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0006828 [manganese ion transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0051480 [cytosolic calcium ion homeostasis] GO:0055085 [transmembrane transport] GO:0070588 [calcium ion transmembrane transport] GO:0070679 [inositol 1,4,5 trisphosphate binding] Show all	460 aa 53.1 kDa	No	4