Cell atlas - RFXAP - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

RFXAP

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nuclear speckles

Human cell
	Nucleoplasm

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	RFXAP
Gene description	Regulatory factor X-associated protein
Protein class	Disease related genes Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	1
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nuclear speckles.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nuclear speckles (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA032035
	SHOW MORE

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nuclear speckles.

Main location

Nuclear speckles (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA032035	HEK 293	Nuclear speckles
	HPA032035	RH-30	Nuclear speckles
	HPA032035	U-2 OS	Nuclear speckles

GENE INFORMATION
Gene name	RFXAP
Synonyms
Description	Regulatory factor X-associated protein (HGNC Symbol)
Entrez gene summary	Major histocompatibility (MHC) class II molecules are transmembrane proteins that have a central role in development and control of the immune system. The protein encoded by this gene, along with regulatory factor X-associated ankyrin-containing protein and regulatory factor-5, forms a complex that binds to the X box motif of certain MHC class II gene promoters and activates their transcription. Once bound to the promoter, this complex associates with the non-DNA-binding factor MHC class II transactivator, which controls the cell type specificity and inducibility of MHC class II gene expression. Mutations in this gene have been linked to bare lymphocyte syndrome type II, complementation group D. Transcript variants utilizing different polyA signals have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	13
Cytoband	q13.3
Chromosome location (bp)	36819224 - 36829104
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000133111 (version 83.38)
Entrez gene	5994
UniProt	O00287 (UniProt - Evidence at protein level)
neXtProt	NX_O00287
Antibodypedia	RFXAP antibodies

PROTEIN BROWSER

RFXAP-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RFXAP-001 ENSP00000255476 ENST00000255476	O00287 [Direct mapping] Regulatory factor X-associated protein Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Transcription factors Yet undefined DNA-binding domains Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003713 [transcription coactivator activity] GO:0005634 [nucleus] GO:0045893 [positive regulation of transcription, DNA-templated] Show all	272 aa 28.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.