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Most cancer tissues showed moderate to strong cytoplasmic positivity. Few cases of renal cell carcinomas, skin and lung cancers were weakly stained.
GENE INFORMATION
Gene name
IRS4 (HGNC Symbol)
Synonyms
IRS-4, PY160
Description
Insulin receptor substrate 4 (HGNC Symbol)
Entrez gene summary
IRS4 encodes the insulin receptor substrate 4, a cytoplasmic protein that contains many potential tyrosine and serine/threonine phosphorylation sites. Tyrosine-phosphorylated IRS4 protein has been shown to associate with cytoplasmic signalling molecules that contain SH2 domains. The IRS4 protein is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation.. [provided by RefSeq, Jul 2008]
SCAMPI predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
