Tissue expression of TBC1D8B - Summary - The Human Protein Atlas

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TBC1D8B

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA
MOUSE BRAIN

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	TBC1D8B
Gene description	TBC1 domain family, member 8B (with GRAM domain)
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Tissue enhanced (adrenal gland)
FANTOM5:	Mixed

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in most tissues.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 2 antibodies. HPA023883 , HPA027527
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (adrenal gland)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Mixed

GENE INFORMATION
Gene name	TBC1D8B (HGNC Symbol)
Synonyms	FLJ20298, RP11-321G1.1
Description	TBC1 domain family, member 8B (with GRAM domain) (HGNC Symbol)
Entrez gene summary	This gene encodes a protein with a TBC (Tre-2/Bub2/CDC16) domain. Some mammalian proteins with this domain have been shown to function as Rab-GAPs by binding to specific Rab proteins and affecting their GTPase activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]
Chromosome	X
Cytoband	q22.3
Chromosome location (bp)	106802680 - 106876145
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000133138 (version 83.38)
Entrez gene	54885
UniProt	Q0IIM8 (UniProt - Evidence at protein level)
neXtProt	NX_Q0IIM8
Antibodypedia	TBC1D8B antibodies

PROTEIN BROWSER

TBC1D8B-001	TBC1D8B-002	TBC1D8B-003	TBC1D8B-004	TBC1D8B-005	TBC1D8B-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TBC1D8B-001 ENSP00000349781 ENST00000357242	Q0IIM8 [Direct mapping] TBC1 domain family member 8B Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005509 [calcium ion binding] GO:0043547 [positive regulation of GTPase activity] Show all	1120 aa 128.7 kDa	No	0
TBC1D8B-002 ENSP00000422353 ENST00000460545	D6RC82 [Direct mapping] TBC1 domain family member 8B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		22 aa 2.5 kDa	No	0
TBC1D8B-003 ENSP00000421375 ENST00000481617	D6RFZ2 [Direct mapping] TBC1 domain family member 8B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		419 aa 48.2 kDa	No	0
TBC1D8B-004 ENSP00000310675 ENST00000310452	Q0IIM8 [Direct mapping] TBC1 domain family member 8B Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005509 [calcium ion binding] GO:0043547 [positive regulation of GTPase activity] Show all	632 aa 72.6 kDa	No	0
TBC1D8B-005 ENSP00000396440 ENST00000431860	H0Y552 [Direct mapping] TBC1 domain family member 8B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] Show all	218 aa 25.1 kDa	No	0
TBC1D8B-007 ENSP00000276175 ENST00000276175	J3KN75 [Direct mapping] TBC1 domain family member 8B Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] Show all	1114 aa 128.1 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.