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GGT2

GENERAL INFORMATION

Gene name

 GGT2

Gene description

 Gamma-glutamyltransferase 2

Protein class

 Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (thyroid gland, lung)
GTEx:Group enriched (thyroid gland, kidney)

Protein evidence

 Evidence at protein level

Protein expression

 Selective expression in renal tubules, epididymis, liver and pancreas.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene. Presumed off target binding observed and disregarded.

Reliability score

 Supported based on 2 antibodies.
HPA045635 , HPA047534
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (thyroid gland, lung)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (thyroid gland, kidney)

GENE INFORMATION

Gene name

 GGT2 (HGNC Symbol)

Synonyms

 GGT

Description

 Gamma-glutamyltransferase 2 (HGNC Symbol)

Entrez gene summary

 GGT2 belongs to the gamma-glutamyltransferase (GGT; EC 2.3.2.2) gene family. GGT is a membrane-bound extracellular enzyme that cleaves gamma-glutamyl peptide bonds in glutathione and other peptides and transfers the gamma-glutamyl moiety to acceptors. GGT is also key to glutathione homeostasis because it provides substrates for glutathione synthesis (Heisterkamp et al., 2008 [PubMed 18357469]).[supplied by OMIM, Oct 2008]

Chromosome

 22

Cytoband

 q11.21

Chromosome location (bp)

 21207973 - 21227637

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000133475 (version 83.38)

Entrez gene

 728441

UniProt

 P36268 (UniProt - Evidence at protein level)

neXtProt

 NX_P36268

Antibodypedia

 GGT2 antibodies

PROTEIN BROWSER
GGT2-001
GGT2-002
GGT2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GGT2-001
ENSP00000385601
ENST00000405188
B5MCK8 [Direct mapping]
Inactive gamma-glutamyltranspeptidase 2
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
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GO:0003840 [gamma-glutamyltransferase activity]
GO:0006749 [glutathione metabolic process]
Show all
 559 aa
60.9 kDa 		Yes 1
GGT2-002
ENSP00000385721
ENST00000401924
P36268 [Direct mapping]
Inactive gamma-glutamyltranspeptidase 2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0003840 [gamma-glutamyltransferase activity]
GO:0005783 [endoplasmic reticulum]
GO:0005886 [plasma membrane]
GO:0006749 [glutathione metabolic process]
GO:0006750 [glutathione biosynthetic process]
GO:0006805 [xenobiotic metabolic process]
GO:0019370 [leukotriene biosynthetic process]
GO:0031362 [anchored component of external side of plasma membrane]
GO:0044281 [small molecule metabolic process]
GO:0048471 [perinuclear region of cytoplasm]
GO:0070062 [extracellular exosome]
GO:1901687 [glutathione derivative biosynthetic process]
Show all
 569 aa
61.8 kDa 		Yes 1
GGT2-201
ENSP00000402035
ENST00000424627
P36268 [Direct mapping]
Inactive gamma-glutamyltranspeptidase 2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0003840 [gamma-glutamyltransferase activity]
GO:0005783 [endoplasmic reticulum]
GO:0005886 [plasma membrane]
GO:0006749 [glutathione metabolic process]
GO:0006750 [glutathione biosynthetic process]
GO:0006805 [xenobiotic metabolic process]
GO:0019370 [leukotriene biosynthetic process]
GO:0031362 [anchored component of external side of plasma membrane]
GO:0044281 [small molecule metabolic process]
GO:0048471 [perinuclear region of cytoplasm]
GO:0070062 [extracellular exosome]
GO:1901687 [glutathione derivative biosynthetic process]
Show all
 569 aa
61.8 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.