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MKRN1

GENERAL INFORMATION

Gene name

 MKRN1

Gene description

 Makorin ring finger protein 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 9
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 MKRN1 (HGNC Symbol)

Synonyms

 RNF61

Description

 Makorin ring finger protein 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that belongs to a novel class of zinc finger proteins. The encoded protein functions as a transcriptional co-regulator, and as an E3 ubiquitin ligase that promotes the ubiquitination and proteasomal degradation of target proteins. The protein encoded by this gene is thought to regulate RNA polymerase II-catalyzed transcription. Substrates for this protein's E3 ubiquitin ligase activity include the capsid protein of the West Nile virus and the catalytic subunit of the telomerase ribonucleoprotein. This protein controls cell cycle arrest and apoptosis by regulating p21, a cell cycle regulator, and the tumor suppressor protein p53. Pseudogenes of this gene are present on chromosomes 1, 3, 9, 12 and 20, and on the X chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014]

Chromosome

 7

Cytoband

 q34

Chromosome location (bp)

 140453040 - 140479569

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000133606 (version 83.38)

Entrez gene

 23608

UniProt

 Q9UHC7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UHC7

Antibodypedia

 MKRN1 antibodies

PROTEIN BROWSER
MKRN1-001
MKRN1-002
MKRN1-007
MKRN1-011
MKRN1-012
MKRN1-013
MKRN1-014
MKRN1-015
MKRN1-018

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MKRN1-001
ENSP00000255977
ENST00000255977
Q9UHC7 [Direct mapping]
E3 ubiquitin-protein ligase makorin-1
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000209 [protein polyubiquitination]
GO:0003682 [chromatin binding]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005575 [cellular_component]
GO:0008270 [zinc ion binding]
GO:0016874 [ligase activity]
GO:0044822 [poly(A) RNA binding]
GO:0046872 [metal ion binding]
Show all
 482 aa
53.3 kDa 		No 0
MKRN1-002
ENSP00000416369
ENST00000443720
Q9UHC7 [Direct mapping]
E3 ubiquitin-protein ligase makorin-1
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000209 [protein polyubiquitination]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005575 [cellular_component]
GO:0008270 [zinc ion binding]
GO:0016874 [ligase activity]
GO:0044822 [poly(A) RNA binding]
GO:0046872 [metal ion binding]
Show all
 329 aa
35.2 kDa 		No 0
MKRN1-007
ENSP00000417863
ENST00000474576
Q9UHC7 [Direct mapping]
E3 ubiquitin-protein ligase makorin-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000209 [protein polyubiquitination]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005575 [cellular_component]
GO:0008270 [zinc ion binding]
GO:0016874 [ligase activity]
GO:0044822 [poly(A) RNA binding]
GO:0046872 [metal ion binding]
Show all
 418 aa
47.6 kDa 		No 0
MKRN1-011
ENSP00000418864
ENST00000471104
C9IY57 [Direct mapping]
E3 ubiquitin-protein ligase makorin-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0046872 [metal ion binding]
Show all
 193 aa
21.1 kDa 		No 0
MKRN1-012
ENSP00000418620
ENST00000473444
C9IZP5 [Direct mapping]
E3 ubiquitin-protein ligase makorin-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0046872 [metal ion binding]
Show all
 102 aa
11.3 kDa 		No 0
MKRN1-013
ENSP00000418588
ENST00000467513
C9J031 [Direct mapping]
E3 ubiquitin-protein ligase makorin-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0046872 [metal ion binding]
Show all
 165 aa
18 kDa 		No 0
MKRN1-014
ENSP00000419843
ENST00000494939
C9JYX8 [Direct mapping]
E3 ubiquitin-protein ligase makorin-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0046872 [metal ion binding]
Show all
 136 aa
14.7 kDa 		No 0
MKRN1-015
ENSP00000419894
ENST00000480552
C9JYI0 [Direct mapping]
E3 ubiquitin-protein ligase makorin-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0046872 [metal ion binding]
Show all
 111 aa
12.2 kDa 		No 0
MKRN1-018
ENSP00000417346
ENST00000463142
H7C4H5 [Direct mapping]
E3 ubiquitin-protein ligase makorin-1
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 112 aa
12.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.