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NTS

GENERAL INFORMATION

Gene name

 NTS

Gene description

 Neurotensin

Protein class

 Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (small intestine, stomach)
GTEx:Tissue enhanced (small intestine, pituitary gland, hypothalamus)
FANTOM5:Tissue enriched (small intestine)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in a subset of cells in small intestine and stomach.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA026664
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Nasopharynx
N/A
N/A
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Small intestine

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (small intestine, stomach)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (small intestine, pituitary gland, hypothalamus)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (small intestine)

GENE INFORMATION

Gene name

 NTS

Synonyms

Description

 Neurotensin (HGNC Symbol)

Entrez gene summary

 This gene encodes a common precursor for two peptides, neuromedin N and neurotensin. Neurotensin is a secreted tridecapeptide, which is widely distributed throughout the central nervous system, and may function as a neurotransmitter or a neuromodulator. It may be involved in dopamine-associated pathophysiological events, in the maintenance of gut structure and function, and in the regulation of fat metabolism. Neurotensin also exhibits antimicrobial activity against bacteria and fungi. Tissue-specific processing may lead to the formation in some tissues of larger forms of neuromedin N and neurotensin. The large forms may represent more stable peptides that are also biologically active. [provided by RefSeq, Oct 2014]

Chromosome

 12

Cytoband

 q21.31

Chromosome location (bp)

 85874295 - 85882992

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000133636 (version 83.38)

Entrez gene

 4922

UniProt

 P30990 (UniProt - Evidence at protein level)

neXtProt

 NX_P30990

Antibodypedia

 NTS antibodies

PROTEIN BROWSER
NTS-001
NTS-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NTS-001
ENSP00000256010
ENST00000256010
P30990 [Direct mapping]
Neurotensin/neuromedin N Large neuromedin N Neuromedin N Neurotensin Tail peptide
Q6FH20 [Target identity:100%; Query identity:100%]
NTS protein; Neurotensin, isoform CRA_b; Preproneurotensin/neuromedin N; cDNA, FLJ92347, Homo sapiens neurotensin (NTS), mRNA
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001889 [liver development]
GO:0001975 [response to amphetamine]
GO:0005184 [neuropeptide hormone activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0006972 [hyperosmotic response]
GO:0007165 [signal transduction]
GO:0008542 [visual learning]
GO:0030133 [transport vesicle]
GO:0032355 [response to estradiol]
GO:0042220 [response to cocaine]
GO:0043025 [neuronal cell body]
GO:0043679 [axon terminus]
GO:0048565 [digestive tract development]
GO:0048678 [response to axon injury]
GO:0050880 [regulation of blood vessel size]
GO:0051385 [response to mineralocorticoid]
GO:0051412 [response to corticosterone]
GO:0071285 [cellular response to lithium ion]
GO:0071549 [cellular response to dexamethasone stimulus]
GO:0097332 [response to antipsychotic drug]
GO:1990090 [cellular response to nerve growth factor stimulus]
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 170 aa
19.8 kDa 		Yes 0
NTS-002
ENSP00000448328
ENST00000551529
G3V1X6 [Direct mapping]
Neurotensin, isoform CRA_a; Neurotensin/neuromedin N
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005184 [neuropeptide hormone activity]
GO:0005576 [extracellular region]
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 95 aa
11.2 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.