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SPINK5

GENERAL INFORMATION

Gene name

 SPINK5

Gene description

 Serine peptidase inhibitor, Kazal type 5

Protein class

 Disease related genes
Plasma proteins
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (esophagus, skin, tonsil)
GTEx:Tissue enhanced (esophagus, vagina)
FANTOM5:Group enriched (esophagus, cervix, uterine, tonsil)

Protein evidence

 Evidence at protein level

Protein expression

 Highly selective cytoplasmic expression in squamous epithelium.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA009067 , HPA011351 , CAB015347
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Skin

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (esophagus, skin, tonsil)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (esophagus, vagina)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (esophagus, cervix, uterine, tonsil)

GENE INFORMATION

Gene name

 SPINK5 (HGNC Symbol)

Synonyms

 DKFZp686K19184, FLJ21544, FLJ97536, FLJ97596, FLJ99794, LEKTI, LETKI, NETS, NS, VAKTI

Description

 Serine peptidase inhibitor, Kazal type 5 (HGNC Symbol)

Entrez gene summary

 This gene encodes a multidomain serine protease inhibitor that contains 15 potential inhibitory domains. The encoded preproprotein is proteolytically processed to generate multiple protein products, which may exhibit unique activities and specificities. These proteins may play a role in skin and hair morphogenesis, as well as anti-inflammatory and antimicrobial protection of mucous epithelia. Mutations in this gene may result in Netherton syndrome, a disorder characterized by ichthyosis, defective cornification, and atopy. This gene is present in a gene cluster on chromosome 5. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]

Chromosome

 5

Cytoband

 q32

Chromosome location (bp)

 148025683 - 148137289

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000133710 (version 83.38)

Entrez gene

 11005

UniProt

 Q9NQ38 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NQ38

Antibodypedia

 SPINK5 antibodies

PROTEIN BROWSER
SPINK5-001
SPINK5-002
SPINK5-003
SPINK5-008
SPINK5-011

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SPINK5-001
ENSP00000256084
ENST00000256084
Q9NQ38 [Direct mapping]
Serine protease inhibitor Kazal-type 5 Hemofiltrate peptide HF6478 Hemofiltrate peptide HF7665
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004867 [serine-type endopeptidase inhibitor activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0005938 [cell cortex]
GO:0009913 [epidermal cell differentiation]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0016525 [negative regulation of angiogenesis]
GO:0030198 [extracellular matrix organization]
GO:0030855 [epithelial cell differentiation]
GO:0035315 [hair cell differentiation]
GO:0042640 [anagen]
GO:0045580 [regulation of T cell differentiation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050777 [negative regulation of immune response]
GO:0070062 [extracellular exosome]
GO:0097209 [epidermal lamellar body]
Show all
 1064 aa
120.7 kDa 		Yes 0
SPINK5-002
ENSP00000381472
ENST00000398454
Q9NQ38 [Direct mapping]
Serine protease inhibitor Kazal-type 5 Hemofiltrate peptide HF6478 Hemofiltrate peptide HF7665
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004867 [serine-type endopeptidase inhibitor activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0005938 [cell cortex]
GO:0009913 [epidermal cell differentiation]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0016525 [negative regulation of angiogenesis]
GO:0030198 [extracellular matrix organization]
GO:0030855 [epithelial cell differentiation]
GO:0035315 [hair cell differentiation]
GO:0042640 [anagen]
GO:0045580 [regulation of T cell differentiation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050777 [negative regulation of immune response]
GO:0070062 [extracellular exosome]
GO:0097209 [epidermal lamellar body]
Show all
 916 aa
104 kDa 		Yes 0
SPINK5-003
ENSP00000352936
ENST00000359874
Q9NQ38 [Direct mapping]
Serine protease inhibitor Kazal-type 5 Hemofiltrate peptide HF6478 Hemofiltrate peptide HF7665
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002787 [negative regulation of antibacterial peptide production]
GO:0004867 [serine-type endopeptidase inhibitor activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0005938 [cell cortex]
GO:0009913 [epidermal cell differentiation]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0016525 [negative regulation of angiogenesis]
GO:0030155 [regulation of cell adhesion]
GO:0030198 [extracellular matrix organization]
GO:0030414 [peptidase inhibitor activity]
GO:0030855 [epithelial cell differentiation]
GO:0035315 [hair cell differentiation]
GO:0042640 [anagen]
GO:0045580 [regulation of T cell differentiation]
GO:0045861 [negative regulation of proteolysis]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050777 [negative regulation of immune response]
GO:0070062 [extracellular exosome]
GO:0097209 [epidermal lamellar body]
GO:1900004 [negative regulation of serine-type endopeptidase activity]
GO:1902572 [negative regulation of serine-type peptidase activity]
Show all
 1094 aa
124.1 kDa 		Yes 0
SPINK5-008
ENSP00000421519
ENST00000508733
E7EWP9 [Direct mapping]
Serine protease inhibitor Kazal-type 5
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 869 aa
98.5 kDa 		Yes 0
SPINK5-011
ENSP00000430264
ENST00000521206
E5RG22 [Direct mapping]
Serine protease inhibitor Kazal-type 5
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 68 aa
7.6 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.