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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
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LYVE1
  • premium

    TISSUE

  • CELL

  • CANCER

CANCER ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

CANCER ATLAS

Gene description

Lymphatic vessel endothelial hyaluronan receptor 1

Protein class

Plasma proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY

HPA042953
CAB025860

Tissue

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Tissue

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Several colorectal and prostate cancers along with a few cases of breast, ovarian, stomach and pancreatic cancers showed moderate to strong cytoplasmic positivity. Remaining cancers were generally negative.

Tissue

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Tissue

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Cancer cells were in general negative.

GENE INFORMATION

Gene name

LYVE1 (HGNC Symbol)

Synonyms

LYVE-1, XLKD1

Description

Lymphatic vessel endothelial hyaluronan receptor 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a type I integral membrane glycoprotein. The encoded protein acts as a receptor and binds to both soluble and immobilized hyaluronan. This protein may function in lymphatic hyaluronan transport and have a role in tumor metastasis. [provided by RefSeq, Jul 2008]

Chromosome

11

Cytoband

p15.4

Chromosome location (bp)

10556966 - 10611689

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000133800 (version 83.38)

Entrez gene

10894

UniProt

Q9Y5Y7 (UniProt - Evidence at protein level)

neXtProt

NX_Q9Y5Y7

Antibodypedia

LYVE1 antibodies

PROTEIN BROWSER

LYVE1-001
LYVE1-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

LYVE1-001
ENSP00000256178
ENST00000256178
Q9Y5Y7 [Direct mapping]
Lymphatic vessel endothelial hyaluronic acid receptor 1
B2R672 [Target identity:100%; Query identity:100%]
Extracellular link domain containing 1; cDNA PSEC0135 fis, clone PLACE1004850, highly similar to Homo sapiens extracellular link domain containing 1 (XLKD1), mRNA; cDNA, FLJ92817, highly similar to Homo sapiens extracellular link domain containing 1 (XLKD1), mRNA
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004872 [receptor activity]
GO:0004888 [transmembrane signaling receptor activity]
GO:0005515 [protein binding]
GO:0005540 [hyaluronic acid binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0006027 [glycosaminoglycan catabolic process]
GO:0006810 [transport]
GO:0006928 [movement of cell or subcellular component]
GO:0007155 [cell adhesion]
GO:0007160 [cell-matrix adhesion]
GO:0007165 [signal transduction]
GO:0009611 [response to wounding]
GO:0009653 [anatomical structure morphogenesis]
GO:0016020 [membrane]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0030212 [hyaluronan metabolic process]
GO:0030214 [hyaluronan catabolic process]
GO:0044281 [small molecule metabolic process]
GO:0070062 [extracellular exosome]
GO:0071944 [cell periphery]
Show all
322 aa
35.2 kDa
Yes 1
LYVE1-003
ENSP00000436016
ENST00000529598
F2Z296 [Direct mapping]
Lymphatic vessel endothelial hyaluronic acid receptor 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016021 [integral component of membrane]
Show all
218 aa
24 kDa
Yes 1

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The Human Protein Atlas project is funded
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