Expression of LYVE1 in cancer - Summary

CANCER ATLAS

Gene description

Lymphatic vessel endothelial hyaluronan receptor 1

Protein class

Plasma proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

STAINING SUMMARY

HPA042953	CAB025860

GENE INFORMATION
Gene name	LYVE1 (HGNC Symbol)
Synonyms	LYVE-1, XLKD1
Description	Lymphatic vessel endothelial hyaluronan receptor 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a type I integral membrane glycoprotein. The encoded protein acts as a receptor and binds to both soluble and immobilized hyaluronan. This protein may function in lymphatic hyaluronan transport and have a role in tumor metastasis. [provided by RefSeq, Jul 2008]
Chromosome	11
Cytoband	p15.4
Chromosome location (bp)	10556966 - 10611689
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000133800 (version 83.38)
Entrez gene	10894
UniProt	Q9Y5Y7 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y5Y7
Antibodypedia	LYVE1 antibodies

PROTEIN BROWSER

LYVE1-001	LYVE1-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LYVE1-001 ENSP00000256178 ENST00000256178	Q9Y5Y7 [Direct mapping] Lymphatic vessel endothelial hyaluronic acid receptor 1 B2R672 [Target identity:100%; Query identity:100%] Extracellular link domain containing 1; cDNA PSEC0135 fis, clone PLACE1004850, highly similar to Homo sapiens extracellular link domain containing 1 (XLKD1), mRNA; cDNA, FLJ92817, highly similar to Homo sapiens extracellular link domain containing 1 (XLKD1), mRNA Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004872 [receptor activity] GO:0004888 [transmembrane signaling receptor activity] GO:0005515 [protein binding] GO:0005540 [hyaluronic acid binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005975 [carbohydrate metabolic process] GO:0006027 [glycosaminoglycan catabolic process] GO:0006810 [transport] GO:0006928 [movement of cell or subcellular component] GO:0007155 [cell adhesion] GO:0007160 [cell-matrix adhesion] GO:0007165 [signal transduction] GO:0009611 [response to wounding] GO:0009653 [anatomical structure morphogenesis] GO:0016020 [membrane] GO:0030203 [glycosaminoglycan metabolic process] GO:0030212 [hyaluronan metabolic process] GO:0030214 [hyaluronan catabolic process] GO:0044281 [small molecule metabolic process] GO:0070062 [extracellular exosome] GO:0071944 [cell periphery] Show all	322 aa 35.2 kDa	Yes	1
LYVE1-003 ENSP00000436016 ENST00000529598	F2Z296 [Direct mapping] Lymphatic vessel endothelial hyaluronic acid receptor 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	218 aa 24 kDa	Yes	1