Cell atlas - AMPD3 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

AMPD3

TISSUE

premium

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nuclear membrane

Human cell
	Nuclear membrane

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	AMPD3
Gene description	Adenosine monophosphate deaminase 3
Protein class	Disease related genes Enzymes Plasma proteins Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nuclear membrane.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Nuclear membrane (validated)

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. HPA038662 , HPA047408
	SHOW MORE

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nuclear membrane.

Main location

Nuclear membrane (validated)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA038662	A-431	Nuclear membrane
	HPA038662	PC-3	Nuclear membrane
	HPA038662	U-2 OS	Nuclear membrane
	HPA047408	A-431	Nuclear membrane
	HPA047408	A-431	Cytosol
	HPA047408	PC-3	Nuclear membrane
	HPA047408	PC-3	Nucleoli
	HPA047408	U-2 OS	Nuclear membrane
	HPA047408	U-2 OS	Nucleoli

GENE INFORMATION
Gene name	AMPD3
Synonyms
Description	Adenosine monophosphate deaminase 3 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the AMP deaminase gene family. The encoded protein is a highly regulated enzyme that catalyzes the hydrolytic deamination of adenosine monophosphate to inosine monophosphate, a branch point in the adenylate catabolic pathway. This gene encodes the erythrocyte (E) isoforms, whereas other family members encode isoforms that predominate in muscle (M) and liver (L) cells. Mutations in this gene lead to the clinically asymptomatic, autosomal recessive condition erythrocyte AMP deaminase deficiency. Alternatively spliced transcript variants encoding different isoforms of this gene have been described. [provided by RefSeq, Jul 2008]
Chromosome	11
Cytoband	p15.4
Chromosome location (bp)	10308313 - 10507579
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000133805 (version 83.38)
Entrez gene	272
UniProt	Q01432 (UniProt - Evidence at protein level)
neXtProt	NX_Q01432
Antibodypedia	AMPD3 antibodies

PROTEIN BROWSER

AMPD3-001	AMPD3-002	AMPD3-003	AMPD3-004	AMPD3-005	AMPD3-014	AMPD3-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AMPD3-001 ENSP00000379802 ENST00000396554	Q01432 [Direct mapping] AMP deaminase 3 Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003876 [AMP deaminase activity] GO:0005829 [cytosol] GO:0006144 [purine nucleobase metabolic process] GO:0006188 [IMP biosynthetic process] GO:0006196 [AMP catabolic process] GO:0009168 [purine ribonucleoside monophosphate biosynthetic process] GO:0019239 [deaminase activity] GO:0032264 [IMP salvage] GO:0034101 [erythrocyte homeostasis] GO:0043101 [purine-containing compound salvage] GO:0044281 [small molecule metabolic process] GO:0046031 [ADP metabolic process] GO:0046033 [AMP metabolic process] GO:0046034 [ATP metabolic process] GO:0046039 [GTP metabolic process] GO:0046872 [metal ion binding] GO:0055086 [nucleobase-containing small molecule metabolic process] GO:0097009 [energy homeostasis] Show all	776 aa 89.7 kDa	No	0
AMPD3-002 ENSP00000433284 ENST00000524866	E9PLK6 [Direct mapping] AMP deaminase 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003876 [AMP deaminase activity] GO:0032264 [IMP salvage] Show all	267 aa 30.1 kDa	No	0
AMPD3-003 ENSP00000379801 ENST00000396553	Q01432 [Direct mapping] AMP deaminase 3 Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003876 [AMP deaminase activity] GO:0005829 [cytosol] GO:0006144 [purine nucleobase metabolic process] GO:0006196 [AMP catabolic process] GO:0009168 [purine ribonucleoside monophosphate biosynthetic process] GO:0019239 [deaminase activity] GO:0032264 [IMP salvage] GO:0043101 [purine-containing compound salvage] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0055086 [nucleobase-containing small molecule metabolic process] Show all	767 aa 88.8 kDa	No	0
AMPD3-004 ENSP00000436987 ENST00000528723	Q01432 [Direct mapping] AMP deaminase 3 Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003876 [AMP deaminase activity] GO:0005829 [cytosol] GO:0006144 [purine nucleobase metabolic process] GO:0006196 [AMP catabolic process] GO:0009168 [purine ribonucleoside monophosphate biosynthetic process] GO:0019239 [deaminase activity] GO:0032264 [IMP salvage] GO:0043101 [purine-containing compound salvage] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0055086 [nucleobase-containing small molecule metabolic process] Show all	774 aa 89.5 kDa	No	0
AMPD3-005 ENSP00000431648 ENST00000529507	Q01432 [Direct mapping] AMP deaminase 3 Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003876 [AMP deaminase activity] GO:0005829 [cytosol] GO:0006144 [purine nucleobase metabolic process] GO:0006196 [AMP catabolic process] GO:0009168 [purine ribonucleoside monophosphate biosynthetic process] GO:0019239 [deaminase activity] GO:0032264 [IMP salvage] GO:0043101 [purine-containing compound salvage] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0055086 [nucleobase-containing small molecule metabolic process] Show all	767 aa 88.8 kDa	No	0
AMPD3-014 ENSP00000432707 ENST00000532250	E9PPG2 [Direct mapping] AMP deaminase 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003876 [AMP deaminase activity] GO:0032264 [IMP salvage] Show all	111 aa 12.6 kDa	No	0
AMPD3-201 ENSP00000396000 ENST00000444303	Q01432 [Direct mapping] AMP deaminase 3 Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003876 [AMP deaminase activity] GO:0005829 [cytosol] GO:0006144 [purine nucleobase metabolic process] GO:0006196 [AMP catabolic process] GO:0009168 [purine ribonucleoside monophosphate biosynthetic process] GO:0019239 [deaminase activity] GO:0032264 [IMP salvage] GO:0043101 [purine-containing compound salvage] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0055086 [nucleobase-containing small molecule metabolic process] Show all	608 aa 71.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.