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DUSP26

GENERAL INFORMATION

Gene name

 DUSP26

Gene description

 Dual specificity phosphatase 26 (putative)

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (skeletal muscle, cerebral cortex)
GTEx:Tissue enhanced (skeletal muscle)
FANTOM5:Tissue enhanced (skeletal muscle)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several tissues, most abundant in neurons of CNS.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA018221
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Hippocampus

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (skeletal muscle, cerebral cortex)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (skeletal muscle)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (skeletal muscle)

GENE INFORMATION

Gene name

 DUSP26 (HGNC Symbol)

Synonyms

 DUSP24, MGC1136

Description

 Dual specificity phosphatase 26 (putative) (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the tyrosine phosphatase family of proteins and exhibits dual specificity by dephosphorylating tyrosine as well as serine and threonine residues. This gene has been described as both a tumor suppressor and an oncogene depending on the cellular context. This protein may regulate neuronal proliferation and has been implicated in the progression of glioblastoma through its ability to dephosphorylate the p53 tumor suppressor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

Chromosome

 8

Cytoband

 p12

Chromosome location (bp)

 33591332 - 33600106

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000133878 (version 83.38)

Entrez gene

 78986

UniProt

 Q9BV47 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BV47

Antibodypedia

 DUSP26 antibodies

PROTEIN BROWSER
DUSP26-001
DUSP26-002
DUSP26-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DUSP26-001
ENSP00000256261
ENST00000256261
Q9BV47 [Direct mapping]
Dual specificity protein phosphatase 26
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Enzymes
   ENZYME proteins
   Hydrolases
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001102 [RNA polymerase II activating transcription factor binding]
GO:0002039 [p53 binding]
GO:0004647 [phosphoserine phosphatase activity]
GO:0004721 [phosphoprotein phosphatase activity]
GO:0004725 [protein tyrosine phosphatase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005794 [Golgi apparatus]
GO:0006470 [protein dephosphorylation]
GO:0008138 [protein tyrosine/serine/threonine phosphatase activity]
GO:0016311 [dephosphorylation]
GO:0016791 [phosphatase activity]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
GO:0044387 [negative regulation of protein kinase activity by regulation of protein phosphorylation]
GO:0045785 [positive regulation of cell adhesion]
GO:0070062 [extracellular exosome]
GO:0070373 [negative regulation of ERK1 and ERK2 cascade]
GO:1902310 [positive regulation of peptidyl-serine dephosphorylation]
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 211 aa
23.9 kDa 		No 0
DUSP26-002
ENSP00000430922
ENST00000522982
E5RHD0 [Direct mapping]
Dual-specificity protein phosphatase 26
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Predicted intracellular proteins
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GO:0006470 [protein dephosphorylation]
GO:0008138 [protein tyrosine/serine/threonine phosphatase activity]
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 146 aa
16.6 kDa 		No 0
DUSP26-003
ENSP00000429176
ENST00000523956
Q9BV47 [Direct mapping]
Dual specificity protein phosphatase 26
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Enzymes
   ENZYME proteins
   Hydrolases
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001102 [RNA polymerase II activating transcription factor binding]
GO:0002039 [p53 binding]
GO:0004647 [phosphoserine phosphatase activity]
GO:0004721 [phosphoprotein phosphatase activity]
GO:0004725 [protein tyrosine phosphatase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0006470 [protein dephosphorylation]
GO:0008138 [protein tyrosine/serine/threonine phosphatase activity]
GO:0016311 [dephosphorylation]
GO:0016791 [phosphatase activity]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
GO:0044387 [negative regulation of protein kinase activity by regulation of protein phosphorylation]
GO:0045785 [positive regulation of cell adhesion]
GO:0070062 [extracellular exosome]
GO:0070373 [negative regulation of ERK1 and ERK2 cascade]
GO:1902310 [positive regulation of peptidyl-serine dephosphorylation]
Show all
 211 aa
23.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.