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MEN1

CANCER ATLAS

Gene description

 Multiple endocrine neoplasia I

Protein class

 Cancer-related genes, Disease related genes, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA030342

GENE INFORMATION

Gene name

 MEN1

Synonyms

Description

 Multiple endocrine neoplasia I (HGNC Symbol)

Entrez gene summary

 This gene encodes menin, a putative tumor suppressor associated with a syndrome known as multiple endocrine neoplasia type 1. In vitro studies have shown menin is localized to the nucleus, possesses two functional nuclear localization signals, and inhibits transcriptional activation by JunD, however, the function of this protein is not known. Two messages have been detected on northern blots but the larger message has not been characterized. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2008]

Chromosome

 11

Cytoband

 q13.1

Chromosome location (bp)

 64803510 - 64811294

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000133895 (version 83.38)

Entrez gene

 4221

UniProt

 O00255 (UniProt - Evidence at protein level)

neXtProt

 NX_O00255

Antibodypedia

 MEN1 antibodies

PROTEIN BROWSER
«
MEN1-001
MEN1-002
MEN1-003
MEN1-004
MEN1-005
MEN1-006
MEN1-007
MEN1-008
MEN1-009
MEN1-010
MEN1-011
MEN1-201
MEN1-202
MEN1-203
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MEN1-001
ENSP00000308975
ENST00000312049
O00255 [Direct mapping]
Menin
Show all
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Large Deletions
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000165 [MAPK cascade]
GO:0000400 [four-way junction DNA binding]
GO:0000403 [Y-form DNA binding]
GO:0000785 [chromatin]
GO:0001933 [negative regulation of protein phosphorylation]
GO:0002076 [osteoblast development]
GO:0003682 [chromatin binding]
GO:0003690 [double-stranded DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006281 [DNA repair]
GO:0006351 [transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008285 [negative regulation of cell proliferation]
GO:0009411 [response to UV]
GO:0010332 [response to gamma radiation]
GO:0010467 [gene expression]
GO:0016363 [nuclear matrix]
GO:0018024 [histone-lysine N-methyltransferase activity]
GO:0030511 [positive regulation of transforming growth factor beta receptor signaling pathway]
GO:0030674 [protein binding, bridging]
GO:0032092 [positive regulation of protein binding]
GO:0032154 [cleavage furrow]
GO:0034968 [histone lysine methylation]
GO:0035097 [histone methyltransferase complex]
GO:0043234 [protein complex]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045668 [negative regulation of osteoblast differentiation]
GO:0045736 [negative regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0045786 [negative regulation of cell cycle]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046329 [negative regulation of JNK cascade]
GO:0047485 [protein N-terminus binding]
GO:0051974 [negative regulation of telomerase activity]
GO:0070412 [R-SMAD binding]
Show all
 610 aa
67.5 kDa 		No 0
MEN1-002
ENSP00000366538
ENST00000377321
O00255 [Direct mapping]
Menin
Show all
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Large Deletions
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000165 [MAPK cascade]
GO:0000400 [four-way junction DNA binding]
GO:0000403 [Y-form DNA binding]
GO:0000785 [chromatin]
GO:0001933 [negative regulation of protein phosphorylation]
GO:0002076 [osteoblast development]
GO:0003682 [chromatin binding]
GO:0003690 [double-stranded DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006281 [DNA repair]
GO:0006351 [transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008285 [negative regulation of cell proliferation]
GO:0009411 [response to UV]
GO:0010332 [response to gamma radiation]
GO:0010467 [gene expression]
GO:0016363 [nuclear matrix]
GO:0018024 [histone-lysine N-methyltransferase activity]
GO:0030511 [positive regulation of transforming growth factor beta receptor signaling pathway]
GO:0030674 [protein binding, bridging]
GO:0032092 [positive regulation of protein binding]
GO:0032154 [cleavage furrow]
GO:0034968 [histone lysine methylation]
GO:0035097 [histone methyltransferase complex]
GO:0043234 [protein complex]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045668 [negative regulation of osteoblast differentiation]
GO:0045736 [negative regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0045786 [negative regulation of cell cycle]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046329 [negative regulation of JNK cascade]
GO:0047485 [protein N-terminus binding]
GO:0051974 [negative regulation of telomerase activity]
GO:0070412 [R-SMAD binding]
Show all
 575 aa
63.7 kDa 		No 0
MEN1-003
ENSP00000323747
ENST00000315422
O00255 [Direct mapping]
Menin
Show all
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Large Deletions
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000165 [MAPK cascade]
GO:0000400 [four-way junction DNA binding]
GO:0000403 [Y-form DNA binding]
GO:0000785 [chromatin]
GO:0001933 [negative regulation of protein phosphorylation]
GO:0002076 [osteoblast development]
GO:0003682 [chromatin binding]
GO:0003690 [double-stranded DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006281 [DNA repair]
GO:0006351 [transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008285 [negative regulation of cell proliferation]
GO:0009411 [response to UV]
GO:0010332 [response to gamma radiation]
GO:0010467 [gene expression]
GO:0016363 [nuclear matrix]
GO:0018024 [histone-lysine N-methyltransferase activity]
GO:0030511 [positive regulation of transforming growth factor beta receptor signaling pathway]
GO:0030674 [protein binding, bridging]
GO:0032092 [positive regulation of protein binding]
GO:0032154 [cleavage furrow]
GO:0034968 [histone lysine methylation]
GO:0035097 [histone methyltransferase complex]
GO:0043234 [protein complex]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045668 [negative regulation of osteoblast differentiation]
GO:0045736 [negative regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0045786 [negative regulation of cell cycle]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046329 [negative regulation of JNK cascade]
GO:0047485 [protein N-terminus binding]
GO:0051974 [negative regulation of telomerase activity]
GO:0070412 [R-SMAD binding]
Show all
 610 aa
67.5 kDa 		No 0
MEN1-004
ENSP00000394933
ENST00000450708
E7EPR4 [Direct mapping]
Menin
Show all
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Large Deletions
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003682 [chromatin binding]
GO:0005634 [nucleus]
Show all
 281 aa
31.1 kDa 		No 0
MEN1-005
ENSP00000402752
ENST00000429702
Q9GZQ5 [Direct mapping]
Menin
Show all
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Large Deletions
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003682 [chromatin binding]
GO:0005634 [nucleus]
Show all
 146 aa
16.1 kDa 		No 0
MEN1-006
ENSP00000388016
ENST00000424912
Q9GZQ5 [Direct mapping]
Menin
Show all
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Large Deletions
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003682 [chromatin binding]
GO:0005634 [nucleus]
Show all
 146 aa
16.1 kDa 		No 0
MEN1-007
ENSP00000366543
ENST00000377326
O00255 [Direct mapping]
Menin
Show all
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Large Deletions
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000165 [MAPK cascade]
GO:0000400 [four-way junction DNA binding]
GO:0000403 [Y-form DNA binding]
GO:0000785 [chromatin]
GO:0001933 [negative regulation of protein phosphorylation]
GO:0002076 [osteoblast development]
GO:0003682 [chromatin binding]
GO:0003690 [double-stranded DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006281 [DNA repair]
GO:0006351 [transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008285 [negative regulation of cell proliferation]
GO:0009411 [response to UV]
GO:0010332 [response to gamma radiation]
GO:0010467 [gene expression]
GO:0016363 [nuclear matrix]
GO:0018024 [histone-lysine N-methyltransferase activity]
GO:0030511 [positive regulation of transforming growth factor beta receptor signaling pathway]
GO:0030674 [protein binding, bridging]
GO:0032092 [positive regulation of protein binding]
GO:0032154 [cleavage furrow]
GO:0034968 [histone lysine methylation]
GO:0035097 [histone methyltransferase complex]
GO:0043234 [protein complex]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045668 [negative regulation of osteoblast differentiation]
GO:0045736 [negative regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0045786 [negative regulation of cell cycle]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046329 [negative regulation of JNK cascade]
GO:0047485 [protein N-terminus binding]
GO:0051974 [negative regulation of telomerase activity]
GO:0070412 [R-SMAD binding]
Show all
 610 aa
67.5 kDa 		No 0
MEN1-008
ENSP00000366533
ENST00000377316
E7EN32 [Direct mapping]
Menin
Show all
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Large Deletions
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003682 [chromatin binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
Show all
 555 aa
61.4 kDa 		No 0
MEN1-009
ENSP00000413944
ENST00000440873
E7ET29 [Direct mapping]
Menin
Show all
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Large Deletions
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003682 [chromatin binding]
GO:0005634 [nucleus]
Show all
 346 aa
38.6 kDa 		No 0
MEN1-010
ENSP00000411218
ENST00000413626
E7ENS2 [Direct mapping]
Menin
Show all
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Large Deletions
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003682 [chromatin binding]
GO:0005634 [nucleus]
Show all
 261 aa
28.7 kDa 		No 0
MEN1-011
ENSP00000366530
ENST00000377313
O00255 [Direct mapping]
Menin
Show all
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Large Deletions
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000165 [MAPK cascade]
GO:0000400 [four-way junction DNA binding]
GO:0000403 [Y-form DNA binding]
GO:0000785 [chromatin]
GO:0001933 [negative regulation of protein phosphorylation]
GO:0002076 [osteoblast development]
GO:0003682 [chromatin binding]
GO:0003690 [double-stranded DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006281 [DNA repair]
GO:0006351 [transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008285 [negative regulation of cell proliferation]
GO:0009411 [response to UV]
GO:0010332 [response to gamma radiation]
GO:0010467 [gene expression]
GO:0016363 [nuclear matrix]
GO:0018024 [histone-lysine N-methyltransferase activity]
GO:0030511 [positive regulation of transforming growth factor beta receptor signaling pathway]
GO:0030674 [protein binding, bridging]
GO:0032092 [positive regulation of protein binding]
GO:0032154 [cleavage furrow]
GO:0034968 [histone lysine methylation]
GO:0035097 [histone methyltransferase complex]
GO:0043234 [protein complex]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045668 [negative regulation of osteoblast differentiation]
GO:0045736 [negative regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0045786 [negative regulation of cell cycle]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046329 [negative regulation of JNK cascade]
GO:0047485 [protein N-terminus binding]
GO:0051974 [negative regulation of telomerase activity]
GO:0070412 [R-SMAD binding]
Show all
 615 aa
68 kDa 		No 0
MEN1-201
ENSP00000337088
ENST00000337652
O00255 [Direct mapping]
Menin
Show all
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Large Deletions
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000165 [MAPK cascade]
GO:0000278 [mitotic cell cycle]
GO:0000400 [four-way junction DNA binding]
GO:0000403 [Y-form DNA binding]
GO:0000785 [chromatin]
GO:0001933 [negative regulation of protein phosphorylation]
GO:0002076 [osteoblast development]
GO:0003309 [type B pancreatic cell differentiation]
GO:0003682 [chromatin binding]
GO:0003690 [double-stranded DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006281 [DNA repair]
GO:0006351 [transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007420 [brain development]
GO:0008285 [negative regulation of cell proliferation]
GO:0009411 [response to UV]
GO:0010332 [response to gamma radiation]
GO:0010467 [gene expression]
GO:0010812 [negative regulation of cell-substrate adhesion]
GO:0016363 [nuclear matrix]
GO:0018024 [histone-lysine N-methyltransferase activity]
GO:0030511 [positive regulation of transforming growth factor beta receptor signaling pathway]
GO:0030674 [protein binding, bridging]
GO:0032092 [positive regulation of protein binding]
GO:0032154 [cleavage furrow]
GO:0032925 [regulation of activin receptor signaling pathway]
GO:0034968 [histone lysine methylation]
GO:0035097 [histone methyltransferase complex]
GO:0043234 [protein complex]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045668 [negative regulation of osteoblast differentiation]
GO:0045736 [negative regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0045786 [negative regulation of cell cycle]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046329 [negative regulation of JNK cascade]
GO:0046697 [decidualization]
GO:0047485 [protein N-terminus binding]
GO:0050680 [negative regulation of epithelial cell proliferation]
GO:0051974 [negative regulation of telomerase activity]
GO:0061469 [regulation of type B pancreatic cell proliferation]
GO:0070412 [R-SMAD binding]
GO:0071333 [cellular response to glucose stimulus]
GO:0071375 [cellular response to peptide hormone stimulus]
GO:0071559 [response to transforming growth factor beta]
GO:1902807 [negative regulation of cell cycle G1/S phase transition]
Show all
 615 aa
68 kDa 		No 0
MEN1-202
ENSP00000377899
ENST00000394374
O00255 [Direct mapping]
Menin
Show all
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Large Deletions
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000165 [MAPK cascade]
GO:0000400 [four-way junction DNA binding]
GO:0000403 [Y-form DNA binding]
GO:0000785 [chromatin]
GO:0001933 [negative regulation of protein phosphorylation]
GO:0002076 [osteoblast development]
GO:0003682 [chromatin binding]
GO:0003690 [double-stranded DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006281 [DNA repair]
GO:0006351 [transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008285 [negative regulation of cell proliferation]
GO:0009411 [response to UV]
GO:0010332 [response to gamma radiation]
GO:0010467 [gene expression]
GO:0016363 [nuclear matrix]
GO:0018024 [histone-lysine N-methyltransferase activity]
GO:0030511 [positive regulation of transforming growth factor beta receptor signaling pathway]
GO:0030674 [protein binding, bridging]
GO:0032092 [positive regulation of protein binding]
GO:0032154 [cleavage furrow]
GO:0034968 [histone lysine methylation]
GO:0035097 [histone methyltransferase complex]
GO:0043234 [protein complex]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045668 [negative regulation of osteoblast differentiation]
GO:0045736 [negative regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0045786 [negative regulation of cell cycle]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046329 [negative regulation of JNK cascade]
GO:0047485 [protein N-terminus binding]
GO:0051974 [negative regulation of telomerase activity]
GO:0070412 [R-SMAD binding]
Show all
 615 aa
68 kDa 		No 0
MEN1-203
ENSP00000377901
ENST00000394376
O00255 [Direct mapping]
Menin
Show all
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Large Deletions
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000165 [MAPK cascade]
GO:0000400 [four-way junction DNA binding]
GO:0000403 [Y-form DNA binding]
GO:0000785 [chromatin]
GO:0001933 [negative regulation of protein phosphorylation]
GO:0002076 [osteoblast development]
GO:0003682 [chromatin binding]
GO:0003690 [double-stranded DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006281 [DNA repair]
GO:0006351 [transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008285 [negative regulation of cell proliferation]
GO:0009411 [response to UV]
GO:0010332 [response to gamma radiation]
GO:0010467 [gene expression]
GO:0016363 [nuclear matrix]
GO:0018024 [histone-lysine N-methyltransferase activity]
GO:0030511 [positive regulation of transforming growth factor beta receptor signaling pathway]
GO:0030674 [protein binding, bridging]
GO:0032092 [positive regulation of protein binding]
GO:0032154 [cleavage furrow]
GO:0034968 [histone lysine methylation]
GO:0035097 [histone methyltransferase complex]
GO:0043234 [protein complex]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045668 [negative regulation of osteoblast differentiation]
GO:0045736 [negative regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0045786 [negative regulation of cell cycle]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046329 [negative regulation of JNK cascade]
GO:0047485 [protein N-terminus binding]
GO:0051974 [negative regulation of telomerase activity]
GO:0070412 [R-SMAD binding]
Show all
 615 aa
68 kDa 		No 0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.