Tissue expression of CTIF - Summary - The Human Protein Atlas

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CTIF

TISSUE

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CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	CTIF
Gene description	CBP80/20-dependent translation initiation factor
Protein class	Predicted intracellular proteins Transporters
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Mixed
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic and nuclear expression at variable levels in several different cell types.

DATA RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Uncertain based on 2 antibodies. HPA016865 , HPA024801
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Mixed
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	CTIF (HGNC Symbol)
Synonyms	KIAA0427
Description	CBP80/20-dependent translation initiation factor (HGNC Symbol)
Entrez gene summary	CTIF is a component of the CBP80 (NCBP1; MIM 600469)/CBP20 (NCBP2; MIM 605133) translation initiation complex that binds cotranscriptionally to the cap end of nascent mRNA. The CBP80/CBP20 complex is involved in a simultaneous editing and translation step that recognizes premature termination codons (PTCs) in mRNAs and directs PTC-containing mRNAs toward nonsense-mediated decay (NMD). On mRNAs without PTCs, the CBP80/CBP20 complex is replaced with cytoplasmic mRNA cap-binding proteins, including EIF4G (MIM 600495), and steady-state translation of the mRNAs resumes in the cytoplasm (Kim et al., 2009 [PubMed 19648179]).[supplied by OMIM, Dec 2009]
Chromosome	18
Cytoband	q21.1
Chromosome location (bp)	48539046 - 48863217
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000134030 (version 83.38)
Entrez gene	9811
UniProt	O43310 (UniProt - Evidence at protein level)
neXtProt	NX_O43310
Antibodypedia	CTIF antibodies

PROTEIN BROWSER

CTIF-001	CTIF-003	CTIF-004	CTIF-005	CTIF-006	CTIF-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CTIF-001 ENSP00000256413 ENST00000256413	O43310 [Direct mapping] CBP80/20-dependent translation initiation factor A0A024R259 [Target identity:100%; Query identity:100%] KIAA0427, isoform CRA_a Show all	Transporters Transporter channels and pores Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay] GO:0003723 [RNA binding] GO:0005488 [binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006446 [regulation of translational initiation] GO:0048471 [perinuclear region of cytoplasm] Show all	598 aa 67.6 kDa	No	0
CTIF-003 ENSP00000372459 ENST00000382998	O43310 [Direct mapping] CBP80/20-dependent translation initiation factor Show all	Transporters Transporter channels and pores Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay] GO:0003723 [RNA binding] GO:0005488 [binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006446 [regulation of translational initiation] GO:0048471 [perinuclear region of cytoplasm] Show all	600 aa 67.8 kDa	No	0
CTIF-004 ENSP00000467425 ENST00000591387	K7EPK6 [Direct mapping] CBP80/20-dependent translation initiation factor Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		138 aa 15.3 kDa	No	0
CTIF-005 ENSP00000465405 ENST00000587752	K7EK08 [Direct mapping] CBP80/20-dependent translation initiation factor Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] Show all	194 aa 21.8 kDa	No	0
CTIF-006 ENSP00000467957 ENST00000588345	K7EQS5 [Direct mapping] CBP80/20-dependent translation initiation factor Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		104 aa 11.3 kDa	No	0
CTIF-007 ENSP00000467965 ENST00000591412	K7EQS9 [Direct mapping] CBP80/20-dependent translation initiation factor Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		120 aa 13 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.